Pre- or Per-dialytic Physical Exercise : a Cardioprotective Role?

Summary

This study aims at evaluating, in chronic kidney disease patients on dialysis, the effect of acute per- or pre-dialytic physical exercise on regional myocardial function and myocardial stunning, blood viscosity, arterial stiffness, variability of sinus rhythm, dialysis efficacy, inflammation, mineral and bone disorders, myokines and cardiac remodeling markers.

Conditions

• Chronic Kidney Diseases

Interventions

PROCEDURE

Dialysis without physical exercise

Hemodialysis control condition

PROCEDURE

Dialysis with pre-dialytic physical exercise

Patients will pedal for 30 minutes using a ergometer directly attached to the dialysis bed. The exercise will be performed 60 minutes before connection to hemodialysis.

PROCEDURE

Dialysis with per-dialytic physical exercise

Patients will pedal for 30 minutes using a ergometer directly attached to the dialysis bed. The exercise will start 30 minutes after the start of dialysis.

Sponsors & Collaborators

• AIDER- Santé

  collaborator UNKNOWN

• Avignon University (EA4278 - LaPEC)

  collaborator UNKNOWN

• Pr Philippe OBERT

  collaborator UNKNOWN

• Dr Claire MAUFRAIS

  collaborator UNKNOWN

• University Hospital, Montpellier

  lead OTHER

Principal Investigators

• Jean Paul CRISTOL, MD, PhD · CHU Lapeyronie, Department of Biochemistry and Hormonology, Montpellier, FRANCE

• François ROUBILLE, MD, PhD · CHU ADV, Department of Cardiology, Montpellier, FRANCE

• Cécile TURC-BARON, MD · AIDER Santé, Montpellier, FRANCE

• Jérôme ADDA, MD · CHU ADV, Department of Cardiology, Montpellier, FRANCE

Study Design

Allocation

NA

Purpose

OTHER

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

20 Years

Max Age

79 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-09-24

Primary Completion

2022-10-31

Completion

2023-04-30

Countries

• France

Study Locations