Trial Outcomes & Findings for Brain Network Modulation and Alcohol Use (NCT NCT04828577)
NCT ID: NCT04828577
Last Updated: 2026-02-10
Results Overview
Participants were asked to move a neurofeedback dial to "alcohol" or "goal" directions. For the "alcohol" they were instructed to attempt to crave alcohol, and for the "goal" they were instructed to attempt to project themselves into their future goals. The outcome was measured by the mean correlation of the needle movement compared to the instructed needle movement.
COMPLETED
NA
21 participants
During the real time fMRI scan, approximately 1 hour (single session)
2026-02-10
Participant Flow
Participant milestones
| Measure |
Real Time Neurofeedback
Real time neurofeedback will be based on a classifier of increasing or decreasing alcohol craving/demand fMRI patterns. Participants will try to modulate their brain patterns based on neurofeedback via a visual dial during an fMRI scan. Participants will be told they will be controlling the visual dial.
Real Time Neurofeedback: Participants receive feedback from their own brain activity.
|
|---|---|
|
Overall Study
STARTED
|
21
|
|
Overall Study
COMPLETED
|
21
|
|
Overall Study
NOT COMPLETED
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Brain Network Modulation and Alcohol Use
Baseline characteristics by cohort
| Measure |
Real Time Neurofeedback
n=21 Participants
Real time neurofeedback will be based on a classifier of increasing or decreasing alcohol craving/demand fMRI patterns. Participants will try to modulate their brain patterns based on neurofeedback via a visual dial during an fMRI scan. Participants will be told they will be controlling the visual dial.
Real Time Neurofeedback: Participants receive feedback from their own brain activity.
|
|---|---|
|
Age, Categorical
<=18 years
|
0 Participants
n=41 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
21 Participants
n=41 Participants
|
|
Age, Categorical
>=65 years
|
0 Participants
n=41 Participants
|
|
Sex: Female, Male
Female
|
11 Participants
n=41 Participants
|
|
Sex: Female, Male
Male
|
10 Participants
n=41 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=41 Participants
|
|
Race (NIH/OMB)
Asian
|
1 Participants
n=41 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=41 Participants
|
|
Race (NIH/OMB)
Black or African American
|
3 Participants
n=41 Participants
|
|
Race (NIH/OMB)
White
|
16 Participants
n=41 Participants
|
|
Race (NIH/OMB)
More than one race
|
1 Participants
n=41 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=41 Participants
|
PRIMARY outcome
Timeframe: During the real time fMRI scan, approximately 1 hour (single session)Participants were asked to move a neurofeedback dial to "alcohol" or "goal" directions. For the "alcohol" they were instructed to attempt to crave alcohol, and for the "goal" they were instructed to attempt to project themselves into their future goals. The outcome was measured by the mean correlation of the needle movement compared to the instructed needle movement.
Outcome measures
| Measure |
Real Time Neurofeedback
n=21 Participants
Real time neurofeedback will be based on a classifier of increasing or decreasing alcohol craving/demand fMRI patterns. Participants will try to modulate their brain patterns based on neurofeedback via a visual dial during an fMRI scan. Participants will be told they will be controlling the visual dial.
Real Time Neurofeedback: Participants receive feedback from their own brain activity.
|
|---|---|
|
Neurofeedback Control
|
0.061 correlation coefficient
Standard Deviation 0.190
|
Adverse Events
Real Time Neurofeedback
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place