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SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial

NCT04802408 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 171

Last updated 2025-10-28

No results posted yet for this study

Summary

Adults (aged 18-65 years) recently diagnosed with SARS-CoV-2 infection who use a 4-day combined intervention of nasal washes with 1% baby shampoo solution and oral gargles with Listerine Antiseptic® will have a reduced SARS-CoV-2 viral load compared to those using nasal and oral washes with normal saline. This combined intervention should be acceptable, tolerable and safe in this population. To test this, investigators are conducting a trial comparing the efficacy of a number of washes in reducing the oral and nasal SARS-CoV-2 viral load among adults.

Conditions

  • Covid19
  • SARS-CoV Infection

Interventions

COMBINATION_PRODUCT

Shampoo and saline

Nasal washes with 1% baby shampoo solution and oropharyngeal gargles with saline solution

COMBINATION_PRODUCT

Saline and Listerine

Nasal washes with buffered saline solution and oropharyngeal gargles with Listerine Antiseptic® solution

COMBINATION_PRODUCT

Shampoo and Listerine

Nasal washes with 1% baby shampoo solution and oropharyngeal gargles with Listerine Antiseptic® solution

COMBINATION_PRODUCT

Saline and Saline

Nasal washes with buffered saline solution and oropharyngeal gargles with saline solution

Sponsors & Collaborators

  • AXIOM Real Time Metrics

    collaborator UNKNOWN

  • Analytica Ventures LLC

    collaborator UNKNOWN

  • Milton S. Hershey Medical Center

    lead OTHER

Principal Investigators

  • Rena Kass, MD · Penn State College of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-10-01
Primary Completion
2026-05-30
Completion
2026-05-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04802408 on ClinicalTrials.gov