Prospective Evaluation of Breast-Conserving Surgery Alone in Low-Risk Ductal Carcinoma in Situ (DCIS)
NCT04797299 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 526
Last updated 2025-09-25
Summary
To evaluate whether the combination of clinicopathological factors and the use of the Oncotype DX DCIS score can avoid radiation in women with low risk DCIS who have had breast conserving surgery (BCS)
Conditions
- DCIS
Sponsors & Collaborators
-
Ontario Clinical Oncology Group (OCOG)
lead OTHER
Principal Investigators
-
Eileen Rakovitch, M.D. · Sunnybrook Research Institute, Sunnybrook Health Science
-
Tim Whelan, M.D · Juravinski Cancer Centre
Eligibility
- Min Age
- 46 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-11-23
- Primary Completion
- 2030-11-30
- Completion
- 2035-11-30
Countries
- Canada
Study Locations
More Related Trials
-
Adjuvant Treatment in Premenopausal Breast Cancer
NCT06807749 ·Status: NOT_YET_RECRUITING
-
Mini-invasive Detection of Residual Disease in Breast Cancer Patients in Remission After Primary Chemotherapy
NCT05951699 ·Status: RECRUITING
-
Selective Omission of Sentinel Lymph Node Biopsy in Mastectomy for Ductal Carcinoma in Situ: Identifying Eligible Candidates
NCT05961280 ·Status: COMPLETED
-
Delayed Selective Sentinel Node Biopsy for Patients Undergoing Mastectomy for DCIS
NCT05912569 ·Status: RECRUITING ·Phase: NA
-
Partial Breast Irradiation for Low-risk Ductal Carcinoma In Situ After Breast-conserving Surgery
NCT02617082 ·Status: UNKNOWN
-
Exercise and Cognitive (Brain) Function in Breast Cancer Patients Getting Chemotherapy After Breast Surgery
NCT04616300 ·Status: RECRUITING
-
Optimizing the Care Pathways of Patients Treated for Operable Breast.
NCT02813317 ·Status: COMPLETED
-
Study of the Influence of Ductal Carcinoma in Situ on the Outcome of Invasive Breast Cancer
NCT03669952 ·Status: COMPLETED
-
Studying Cells Collected Through Ductal Lavage in Women Undergoing Surgery for Ductal Carcinoma In Situ or Other Breast Cancer
NCT00896857 ·Status: COMPLETED
-
A Decision Aid for Women With Early Stage Breast Cancer
NCT00201929 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Tumor and Blood Samples From Women With Breast Cancer
NCT00897728 ·Status: UNKNOWN
-
Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast Cancer
NCT00001496 ·Status: COMPLETED
-
The Impact of the Oncotype DX® Breast Cancer Assay on Treatment Decisions in a Canadian Population
NCT02347449 ·Status: COMPLETED ·Phase: NA
-
Breast MRI as a Preoperative Tool for DCIS
NCT00605982 ·Status: COMPLETED ·Phase: NA
-
Acceptability of Active Monitoring (AM) as a Treatment Option for Ductal Carcinoma in Situ (DCIS)
NCT03775213 ·Status: COMPLETED ·Phase: NA
-
Neoadjuvant Complete Response Customized Treatment Approach for Definitive Management of Breast Cancer
NCT07217990 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Personalized Second Chance Breast Conservation (PSCBC): A Prospective Phase II Clinical Study
NCT04371913 ·Status: RECRUITING ·Phase: NA
-
A Study of Changes in Ki67 Expression in People With Breast Cancer Receiving Endocrine Therapy Before Surgery
NCT06127979 ·Status: RECRUITING ·Phase: NA
-
Oncotype DX in BRCA-mutated Breast Cancer Patients: Our Experience. A Retrospective Observational Monocentric Study
NCT06484725 ·Status: COMPLETED
-
InheriteD brEast caNcer iTalian regIsTrY A Retrospective-prospective Observational Cohort Study to Evaluate Cancer Prevention Strategies in Women With a Deleterious Mutation in BRCA1-2
NCT05835739 ·Status: RECRUITING
-
Analysis of Surgery in Patients Presenting With Stage IV Breast Cancer
NCT00941759 ·Status: COMPLETED
-
Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer
NCT00040222 ·Status: COMPLETED
-
Study to Identify Molecular Mechanisms of Clinical Resistance to Chemotherapy in Triple Negative Breast Cancer Patients
NCT01276899 ·Status: COMPLETED
-
Multidisciplinary Approach to Breast Cancer Through the Study of Altered Transcriptomic and Immune Accompanied by the Identification of Extractable Markers From the Radiodiagnostic Bioimaging
NCT05809128 ·Status: UNKNOWN
-
Assessing the Accuracy of Tumor Biopsies After Chemotherapy to Determine if Patients Can Avoid Breast Surgery
NCT03188393 ·Status: COMPLETED ·Phase: PHASE2