Impact of Long Term of Benzodiazepine Use on Psychiatric Manifestation

Summary

Benzodiazepines are usually a secondary drug of abuse-used mainly to augment the high received from another drug or to offset the adverse effects of other drugs. Few cases of addiction arise from legitimate use of benzodiazepines. Pharmacologic dependence, a predictable and natural adaptation of a body system long accustomed to the presence of a drug, may occur in patients taking therapeutic doses of benzodiazepines. However, this dependence, which generally manifests itself in withdrawal symptoms upon the abrupt discontinuation of the medication, may be controlled and ended through dose tapering, medication switching, and/or medication augmentation. Due to the chronic nature of anxiety, long-term low-dose benzodiazepine treatment may be necessary for some patients; this continuation of treatment should not be considered abuse or addiction.

previous study reported that The results of the study are important in that they corroborate the mounting evidence that a range of neuropsychological functions are impaired as a result of long-term benzodiazepine use, and that these are likely to persist even following withdrawal. The findings highlight the residual neurocognitive compromise associated with long-term benzodiazepine therapy as well as the important clinical implications of these results.

Conditions

• Psychiatric Disorder
• Benzodiazepine-Related Disorders

Interventions

BEHAVIORAL

Detailed interview with personal demographic data

, such as age, sex, education, history of occupation, past medical history, family history, medical, neurological, and psychiatric disorders.

BEHAVIORAL

Intelligence assessment using the Arabic version of the Wechsler Adult Intelligence Scale (WAIS)

the test consists of six verbal subtests and five performance subtests. It used in measure Intelligence

BEHAVIORAL

The Arabic version of the Structured Interview for the Five-Factor Personality Model (SIFFM)

it depend on a model of general language personality descriptors that based on theory suggests five broad dimensions to describe human personality

BEHAVIORAL

the Hamilton Depression Rating Scale

it used for evaluation depression severity. It is 17 items and each item's score (0-4). with a total score range of 0-54

BEHAVIORAL

The Hamilton Anxiety Rating Scale

it used for evaluation the severity of anxiety. The scale consists of 14 items and each item is scored on a scale from 0 to 4 , with a total score range of 0-56

BEHAVIORAL

The Minnesota Multiphasic Personality Inventory-2 (MMPI-2)

It used to evaluate range of symptoms of psychopathology and personality traits that are maladaptive. It has 10 clinical scales subscales included the following: 1, hypochondriasis (Hs); 2, depression (D); 3, hysteria (Hy); 4, psychopathic deviation (Pd); 5, masculinity-femininity (Mf); 6, paranoia (Pa); 7, psychophrenia (Pt); 8, schizophrenia (Sc); 9, hypomania (Ma); 10, social introversion (Ma); (Si). More than 65 responses were considered symptomatic

Sponsors & Collaborators

• Assiut University

  lead OTHER

Eligibility

Min Age

18 Years

Max Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-03-10

Primary Completion

2022-06-20

Completion

2023-09-20