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OneinSeven Gestational Diabetes Genetic and Socioeconomic Risk Study

NCT04789473 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 10000

Last updated 2021-06-30

No results posted yet for this study

Summary

The objective of the Gestational Diabetes Genetic Socioeconomic Risk Study is to generate genome wide association study data (GWAS) to calculate polygenic risk scores (PRS) for the development of gestational diabetes in pregnant women. Oshun Medical's GWAS study will be conducted by collecting DNA samples alongside medical and socioeconomic data and applying data science methodology to generate a polygenic risk score algorithm for gestational diabetes. Our hypothesis is that key genetic variants linked to gestational diabetes will be identified, and sociodemographic characteristics may impact epigenetic factors which further contribute to this risk of gestational diabetes. The PRS generated through our study will be combined with an analysis of epigenetic factors to produce a new method for predicting risk of developing gestational diabetes during pregnancy.

Conditions

  • Gestational Diabetes
  • Pregnancy Complications
  • Pregnancy Related
  • Genetic Predisposition
  • Risk Reduction

Interventions

GENETIC

Polygenic Risk Score Generation

PRS will be calculated for gestational diabetes risk using both cohorts, participants wont have results returned to them during the study.

Sponsors & Collaborators

  • Prenome

    lead INDUSTRY

Principal Investigators

  • Barbara Levy, MD · Prenome

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-24
Primary Completion
2022-04-01
Completion
2022-08-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04789473 on ClinicalTrials.gov