The Immunodynamic Effect of Radiotherapy in Prostate Cancer Patients.

Summary

Radiotherapy has an important role in the treatment of prostate cancer both as curative treatment and postoperative or salvage ones. Several studies demonstrated a significant reduction of lymphocytes during RT but there are only a few studies monitoring these cells in the treatment of prostate cancer. This study will enroll 50 patients with hystologically proven prostate cancer who will undergo to radiotherapy according to Institutional protocols.

This study aims to evaluate the effect of RT on immuno-regulatory B, NK, T, B and T lymphocyte subpopulations (Breg and Treg) and plasma cells, quantitative / qualitative changes,their correlations with the clinical course of the disease and acute and late toxicity. In parallel, using multicolor panels (12 colors) we will evaluate the expression of inhibitory checkpoints and TGFβ signaling.

The final objective is to identify new therapeutic targets to be combined with RT.

Conditions

• Prostatic Neoplasm

Interventions

DIAGNOSTIC_TEST

Blood sample

Pazients will undergo to blood samples at predefined times

Sponsors & Collaborators

• Paola Nisticò

  collaborator UNKNOWN

• Iole Cordone

  collaborator UNKNOWN

• Adriana Faiella

  collaborator UNKNOWN

• Paola Trono

  collaborator UNKNOWN

• Serena Masi

  collaborator UNKNOWN

• Roberta Merola

  collaborator UNKNOWN

• Anna Antenucci

  collaborator UNKNOWN

• Maria Laura Foddai

  collaborator UNKNOWN

• Maria Consiglia Ferriero

  collaborator UNKNOWN

• Diana Giannarelli

  collaborator UNKNOWN

• Paolo Di Ridolfi

  collaborator UNKNOWN

• Regina Elena Cancer Institute

  lead OTHER

Principal Investigators

• Giuseppe Sanguineti · IFO

Study Design

Allocation

NA

Purpose

TREATMENT

Masking

SINGLE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

MALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-02-14

Primary Completion

2021-02-25

Completion

2022-01-01

Countries

• Italy

Study Locations