Trial Outcomes & Findings for Log2Lose: Incenting Weight Loss and Dietary Self-monitoring in Real-time to Improve Weight Management Among Adults With Obesity (NCT NCT04770909)

NCT ID: NCT04770909

Last Updated: 2026-05-20

Results Overview

Measured on a calibrated, digital scale to the nearest 0.1 kg

Recruitment status

COMPLETED

Study phase

Target enrollment

706 participants

Primary outcome timeframe

26 weeks

Results posted on

2026-05-20

Participant Flow

3306 unique people completed an online screening survey. 1646 people were deemed eligible for a phone screening survey. 897 people completed phone screening and were eligible for in-person visit. 727 people completed in person visits and were eligible for group classes. Per protocol, participants were randomized to a condition but only considered enrolled if they provided a baseline weight. 706 people provided baseline weight and attended group classes were randomization status was disclosed.

Participant milestones

Participant milestones
Measure	Combined Weekly incentives for dietary self-monitoring and weight loss Incentives for dietary self-monitoring and weight loss: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring and weight loss	Dietary Self-monitoring Weekly incentives for dietary self-monitoring Incentives for dietary self-monitoring: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring	Weight Loss Weekly incentives for weight loss Incentives for weight loss: Participants can earn up to $300 during the trial for achieving weight loss	Control Allocated to no incentives
Overall Study STARTED	175	177	181	173
Overall Study 6-month Analysis Population	160	162	159	147
Overall Study 12-month Analysis Population	150	147	146	139
Overall Study 18-month Analysis Population	145	139	138	135
Overall Study Participants Who Took at Least 1 Medication During the Study Period	70	86	62	71
Overall Study COMPLETED	148	143	140	136
Overall Study NOT COMPLETED	27	34	41	37

Reasons for withdrawal

Reasons for withdrawal
Measure	Combined Weekly incentives for dietary self-monitoring and weight loss Incentives for dietary self-monitoring and weight loss: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring and weight loss	Dietary Self-monitoring Weekly incentives for dietary self-monitoring Incentives for dietary self-monitoring: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring	Weight Loss Weekly incentives for weight loss Incentives for weight loss: Participants can earn up to $300 during the trial for achieving weight loss	Control Allocated to no incentives
Overall Study Lost to Follow-up	10	25	28	24
Overall Study Withdrawal by Subject	17	8	12	13
Overall Study Death	0	1	1	0

Baseline Characteristics

Log2Lose: Incenting Weight Loss and Dietary Self-monitoring in Real-time to Improve Weight Management Among Adults With Obesity

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Combined n=175 Participants Weekly incentives for dietary self-monitoring and weight loss Incentives for dietary self-monitoring and weight loss: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring and weight loss	Dietary Self-monitoring n=177 Participants Weekly incentives for dietary self-monitoring Incentives for dietary self-monitoring: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring	Weight Loss n=181 Participants Weekly incentives for weight loss Incentives for weight loss: Participants can earn up to $300 during the trial for achieving weight loss	Control n=173 Participants Allocated to no incentives	Total n=706 Participants Total of all reporting groups
Age, Continuous	49.7 years STANDARD_DEVIATION 12.9 • n=30 Participants	48.4 years STANDARD_DEVIATION 12.6 • n=30 Participants	46.5 years STANDARD_DEVIATION 13.3 • n=60 Participants	48.1 years STANDARD_DEVIATION 13.2 • n=133 Participants	48.2 years STANDARD_DEVIATION 13.0 • n=6 Participants
Sex: Female, Male Female	138 Participants n=30 Participants	139 Participants n=30 Participants	141 Participants n=60 Participants	135 Participants n=133 Participants	553 Participants n=6 Participants
Sex: Female, Male Male	37 Participants n=30 Participants	38 Participants n=30 Participants	40 Participants n=60 Participants	38 Participants n=133 Participants	153 Participants n=6 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	14 Participants n=30 Participants	10 Participants n=30 Participants	14 Participants n=60 Participants	10 Participants n=133 Participants	48 Participants n=6 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	157 Participants n=30 Participants	163 Participants n=30 Participants	165 Participants n=60 Participants	161 Participants n=133 Participants	646 Participants n=6 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	4 Participants n=30 Participants	4 Participants n=30 Participants	2 Participants n=60 Participants	2 Participants n=133 Participants	12 Participants n=6 Participants
Race (NIH/OMB) American Indian or Alaska Native	1 Participants n=30 Participants	1 Participants n=30 Participants	0 Participants n=60 Participants	2 Participants n=133 Participants	4 Participants n=6 Participants
Race (NIH/OMB) Asian	11 Participants n=30 Participants	5 Participants n=30 Participants	6 Participants n=60 Participants	10 Participants n=133 Participants	32 Participants n=6 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=30 Participants	0 Participants n=30 Participants	0 Participants n=60 Participants	1 Participants n=133 Participants	1 Participants n=6 Participants
Race (NIH/OMB) Black or African American	24 Participants n=30 Participants	36 Participants n=30 Participants	39 Participants n=60 Participants	42 Participants n=133 Participants	141 Participants n=6 Participants
Race (NIH/OMB) White	126 Participants n=30 Participants	127 Participants n=30 Participants	127 Participants n=60 Participants	116 Participants n=133 Participants	496 Participants n=6 Participants
Race (NIH/OMB) More than one race	7 Participants n=30 Participants	4 Participants n=30 Participants	3 Participants n=60 Participants	0 Participants n=133 Participants	14 Participants n=6 Participants
Race (NIH/OMB) Unknown or Not Reported	6 Participants n=30 Participants	4 Participants n=30 Participants	6 Participants n=60 Participants	2 Participants n=133 Participants	18 Participants n=6 Participants
Region of Enrollment United States	175 participants n=30 Participants	177 participants n=30 Participants	181 participants n=60 Participants	173 participants n=133 Participants	706 participants n=6 Participants

PRIMARY outcome

Timeframe: 26 weeks

Measured on a calibrated, digital scale to the nearest 0.1 kg

Outcome measures

Outcome measures
Measure	Dietary Self-monitoring n=162 Participants Weekly incentives for dietary self-monitoring Incentives for dietary self-monitoring: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring	Weight Loss n=159 Participants Weekly incentives for weight loss Incentives for weight loss: Participants can earn up to $300 during the trial for achieving weight loss	Control n=147 Participants Allocated to no incentives	Combined n=160 Participants Weekly incentives for dietary self-monitoring and weight loss Incentives for dietary self-monitoring and weight loss: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring and weight loss
Percent of Participants Who Achieve Clinically Significant Weight Loss of at Least 5 Percent of Baseline Weight at 26 Weeks	43 Participants	48 Participants	32 Participants	40 Participants

SECONDARY outcome

Timeframe: 52 weeks

Measured on a calibrated, digital scale to the nearest 0.1 kg

Outcome measures

Outcome measures
Measure	Dietary Self-monitoring n=147 Participants Weekly incentives for dietary self-monitoring Incentives for dietary self-monitoring: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring	Weight Loss n=146 Participants Weekly incentives for weight loss Incentives for weight loss: Participants can earn up to $300 during the trial for achieving weight loss	Control n=139 Participants Allocated to no incentives	Combined n=150 Participants Weekly incentives for dietary self-monitoring and weight loss Incentives for dietary self-monitoring and weight loss: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring and weight loss
Percent of Participants Who Achieve Clinically Significant Weight Loss of at Least 5 Percent of Baseline Weight at 52 Weeks	47 Participants	53 Participants	41 Participants	48 Participants

SECONDARY outcome

Timeframe: 78 weeks

Measured on a calibrated, digital scale to the nearest 0.1 kg

Outcome measures

Outcome measures
Measure	Dietary Self-monitoring n=139 Participants Weekly incentives for dietary self-monitoring Incentives for dietary self-monitoring: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring	Weight Loss n=138 Participants Weekly incentives for weight loss Incentives for weight loss: Participants can earn up to $300 during the trial for achieving weight loss	Control n=135 Participants Allocated to no incentives	Combined n=145 Participants Weekly incentives for dietary self-monitoring and weight loss Incentives for dietary self-monitoring and weight loss: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring and weight loss
Percent of Participants Who Achieve Clinically Significant Weight Loss of at Least 5 Percent of Baseline Weight at 78 Weeks	48 Participants	44 Participants	41 Participants	47 Participants

SECONDARY outcome

Timeframe: Baseline, 78 weeks

Population: Data reported for all participants, whether they were taking any prescriptions.

Antihypertensive, antilipemic, and type 2 diabetes medications use reported here descriptively as the count of participants who decreased medications, increased medications, or where medications stayed the same.

Outcome measures

Outcome measures
Measure	Dietary Self-monitoring n=177 Participants Weekly incentives for dietary self-monitoring Incentives for dietary self-monitoring: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring	Weight Loss n=181 Participants Weekly incentives for weight loss Incentives for weight loss: Participants can earn up to $300 during the trial for achieving weight loss	Control n=173 Participants Allocated to no incentives	Combined n=175 Participants Weekly incentives for dietary self-monitoring and weight loss Incentives for dietary self-monitoring and weight loss: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring and weight loss
Change in Use of Cardiovascular Medications From Baseline to 78 Weeks for All Participants Participants who Decreased Medications	38 Participants	26 Participants	26 Participants	22 Participants
Change in Use of Cardiovascular Medications From Baseline to 78 Weeks for All Participants Participants who Increased Medications	16 Participants	10 Participants	16 Participants	18 Participants
Change in Use of Cardiovascular Medications From Baseline to 78 Weeks for All Participants Medication Stayed the Same	119 Participants	133 Participants	120 Participants	126 Participants
Change in Use of Cardiovascular Medications From Baseline to 78 Weeks for All Participants Missing	4 Participants	12 Participants	11 Participants	9 Participants

SECONDARY outcome

Timeframe: Baseline, 78 weeks

Population: Data reported for a subset of participants only, those who took at least 1 medication during the study period.

Antihypertensive, antilipemic, and type 2 diabetes medication use, reported here descriptively as the count of participants with any medications who decreased medications, increased medications, or where medications stayed the same.

Outcome measures

Outcome measures
Measure	Dietary Self-monitoring n=86 Participants Weekly incentives for dietary self-monitoring Incentives for dietary self-monitoring: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring	Weight Loss n=62 Participants Weekly incentives for weight loss Incentives for weight loss: Participants can earn up to $300 during the trial for achieving weight loss	Control n=71 Participants Allocated to no incentives	Combined n=70 Participants Weekly incentives for dietary self-monitoring and weight loss Incentives for dietary self-monitoring and weight loss: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring and weight loss
Change in Use of Cardiovascular Medications From Participants Who Took 1 or More Medications From Baseline to 78 Weeks Participants who Decreased Medications	38 Participants	26 Participants	26 Participants	22 Participants
Change in Use of Cardiovascular Medications From Participants Who Took 1 or More Medications From Baseline to 78 Weeks Participants who Increased Medications	16 Participants	10 Participants	16 Participants	18 Participants
Change in Use of Cardiovascular Medications From Participants Who Took 1 or More Medications From Baseline to 78 Weeks Participants with no change in Medications	32 Participants	26 Participants	29 Participants	30 Participants

SECONDARY outcome

Timeframe: baseline, 26, 52, and 78 weeks

Population: Participants were lost to follow up at subsequent time points.

Average of two sequential measurements measured on a digital blood pressure monitor. A second reading will be taken one minute after the first. If the difference between the \*systolic\* measurements is greater than 15mmHg, then a third reading will be taken, one minute after the second reading. Data are model estimated means, baseline values are the same for all groups.

Outcome measures

Outcome measures
Measure	Dietary Self-monitoring n=177 Participants Weekly incentives for dietary self-monitoring Incentives for dietary self-monitoring: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring	Weight Loss n=181 Participants Weekly incentives for weight loss Incentives for weight loss: Participants can earn up to $300 during the trial for achieving weight loss	Control n=173 Participants Allocated to no incentives	Combined n=175 Participants Weekly incentives for dietary self-monitoring and weight loss Incentives for dietary self-monitoring and weight loss: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring and weight loss
Diastolic Blood Pressure 52 weeks	78.93 mmHg Interval 77.36 to 80.49	79.58 mmHg Interval 77.96 to 81.19	79.52 mmHg Interval 77.8 to 81.25	78.13 mmHg Interval 76.58 to 79.69
Diastolic Blood Pressure Baseline	81.31 mmHg Interval 80.51 to 82.1	81.31 mmHg Interval 80.51 to 82.1	81.31 mmHg Interval 80.51 to 82.1	81.31 mmHg Interval 80.51 to 82.1
Diastolic Blood Pressure 26 weeks	81.13 mmHg Interval 79.7 to 82.56	79.09 mmHg Interval 77.63 to 80.55	80.64 mmHg Interval 79.09 to 82.18	79.40 mmHg Interval 78.0 to 80.81
Diastolic Blood Pressure 78 weeks	80.52 mmHg Interval 78.89 to 82.15	78.95 mmHg Interval 77.24 to 80.66	79.44 mmHg Interval 77.68 to 81.21	80.28 mmHg Interval 78.66 to 81.9

SECONDARY outcome

Timeframe: 26, 52, and 78 weeks

Population: Participants were lost to follow up at subsequent time points.

Average of two sequential measurements measured on a digital blood pressure monitor. A second reading will be taken one minute after the first. If the difference between the systolic measurements is greater than 15mmHg, then a third reading will be taken, one minute after the second reading. Data are model estimated means, baseline values are the same for all groups.

Outcome measures

Outcome measures
Measure	Dietary Self-monitoring n=177 Participants Weekly incentives for dietary self-monitoring Incentives for dietary self-monitoring: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring	Weight Loss n=181 Participants Weekly incentives for weight loss Incentives for weight loss: Participants can earn up to $300 during the trial for achieving weight loss	Control n=173 Participants Allocated to no incentives	Combined n=175 Participants Weekly incentives for dietary self-monitoring and weight loss Incentives for dietary self-monitoring and weight loss: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring and weight loss
Systolic Blood Pressure Baseline	124.48 mmHg Interval 123.33 to 125.63	124.48 mmHg Interval 123.33 to 125.63	124.48 mmHg Interval 123.33 to 125.63	124.48 mmHg Interval 123.33 to 125.63
Systolic Blood Pressure 26 weeks	126.02 mmHg Interval 123.83 to 128.2	122.92 mmHg Interval 120.7 to 125.14	126.48 mmHg Interval 124.12 to 128.84	123.56 mmHg Interval 121.39 to 125.72
Systolic Blood Pressure 52 weeks	123.17 mmHg Interval 120.83 to 125.51	123.67 mmHg Interval 121.25 to 126.08	125.10 mmHg Interval 122.52 to 127.67	121.09 mmHg Interval 118.77 to 123.41
Systolic Blood Pressure 78 weeks	123.98 mmHg Interval 121.55 to 126.4	123.30 mmHg Interval 120.76 to 125.84	124.01 mmHg Interval 121.38 to 126.64	123.51 mmHg Interval 121.1 to 125.93

OTHER_PRE_SPECIFIED outcome

Timeframe: 26 weeks

Association of intrinsic motivation for weight loss with proportion of patients who achieve clinically significant weight loss of at least 5 percent of baseline weight at 26 weeks will be measured with modified version of Treatment Self-Regulation Questionnaire. Intrinsic motivation will be calculated as mean of items 2, 4, 6, 8, 11, 14, 16, 17. Each item can be answered from '1 - not at all true' to '6 - very true'. Lower scores correspond to lower intrinsic motivation for weight loss

Outcome measures

Outcome data not reported

OTHER_PRE_SPECIFIED outcome

Timeframe: 26 weeks

Association of extrinsic motivation for weight loss with proportion of patients who achieve clinically significant weight loss of at least 5 percent of baseline weight at 26 weeks will be measured with modified version of Treatment Self-Regulation Questionnaire. Extrinsic motivation will be calculated as mean of items 1, 3, 5, 7, 9, 10, 12, 13, 15, 18. Each item can be answered from '1 - not at all true' to '6 - very true'. Lower scores correspond to lower extrinsic motivation for weight loss

Outcome measures

Outcome data not reported

Adverse Events

Combined

Serious events: 9 serious events

Other events: 44 other events

Deaths: 0 deaths

Dietary Self-monitoring

Serious events: 14 serious events

Other events: 39 other events

Deaths: 1 deaths

Weight Loss

Serious events: 7 serious events

Other events: 37 other events

Deaths: 1 deaths

Control

Serious events: 8 serious events

Other events: 44 other events

Deaths: 0 deaths

Serious adverse events

Other adverse events

Additional Information

Corrine I. Voils, PhD

University of Utah Department of Internal Medicine

Phone: 919-412-7768

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place

Serious adverse events
Measure	Combined n=175 participants at risk Weekly incentives for dietary self-monitoring and weight loss Incentives for dietary self-monitoring and weight loss: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring and weight loss	Dietary Self-monitoring n=177 participants at risk Weekly incentives for dietary self-monitoring Incentives for dietary self-monitoring: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring	Weight Loss n=181 participants at risk Weekly incentives for weight loss Incentives for weight loss: Participants can earn up to $300 during the trial for achieving weight loss	Control n=173 participants at risk Allocated to no incentives
Blood and lymphatic system disorders Fatigue	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Cardiac disorders Cardiac disorder	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Cardiac disorders Heart Failure	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Cardiac disorders Myocardial Infarction	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Cardiac disorders Unspecified Cardiac Block	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Ear and labyrinth disorders Vertigo	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Eye disorders Fuch's Dystrophy	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Eye disorders Macular Hole	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Eye disorders Retinitis Pigmentosa	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Bowel Obstruction	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Diarrhea	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Diverticulitis	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Gastritis	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Gastrointestinal Issues	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Hepatobiliary disorders Gallbladder Necrosis	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Bone Infection	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Human Metapneumovirus	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Injury, poisoning and procedural complications Fall	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	1.2% 2/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Injury, poisoning and procedural complications Fracture	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Musculoskeletal and connective tissue disorders Back Pain	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Musculoskeletal and connective tissue disorders Chest Wall Pain	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Musculoskeletal and connective tissue disorders Disc Bulge	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Musculoskeletal and connective tissue disorders Neck Pain	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Musculoskeletal and connective tissue disorders Pain	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Musculoskeletal and connective tissue disorders Torn Meniscus	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Breast Cancer	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Mass in Throat	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Neoplasms benign, malignant and unspecified (incl cysts and polyps) Uterine Precancerous Cells	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Nervous system disorders Amnesia	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Nervous system disorders Parkinson's Disease	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Renal and urinary disorders Renal Calculi	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Surgical and medical procedures Gallbladder Removal	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	1.1% 2/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Surgical and medical procedures Hernia Repair	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Surgical and medical procedures Herniated Disc Repair	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Surgical and medical procedures Hysterectomy / Uterine Fibroid Removal	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Surgical and medical procedures Inguinal Hernia	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Surgical and medical procedures Tendon Repair	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Surgical and medical procedures Unspecified Cancer Removal Surgery	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Vascular disorders Aneurysm	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Vascular disorders Aortic Dissection	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.

Other adverse events
Measure	Combined n=175 participants at risk Weekly incentives for dietary self-monitoring and weight loss Incentives for dietary self-monitoring and weight loss: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring and weight loss	Dietary Self-monitoring n=177 participants at risk Weekly incentives for dietary self-monitoring Incentives for dietary self-monitoring: Participants can earn up to $300 during the trial for achieving adequate dietary self-monitoring	Weight Loss n=181 participants at risk Weekly incentives for weight loss Incentives for weight loss: Participants can earn up to $300 during the trial for achieving weight loss	Control n=173 participants at risk Allocated to no incentives
Cardiac disorders Atrial Fibrillation	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Cardiac disorders Chest Pain Cardiac	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Cardiac disorders Dyspnea	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Cardiac disorders Gastrointestinal Reflux Disease	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Cardiac disorders Palpitations	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Cardiac disorders Pericardial Effusion	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Ear and labyrinth disorders Vertigo	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	1.1% 2/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Endocrine disorders Hashimoto's Thyroiditis	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Endocrine disorders Thyroid Stimulating Hormone Increased	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Eye disorders Eye Infection	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Constipation	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	1.1% 2/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Gallbladder Sludge	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Gastric Ulcer	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Gastroenteritis	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Gastroesophageal Reflux Disease	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Gastrointestinal Pain	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Irritable Bowel Syndrome	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Irritable Bowel Syndrome Attack	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Nausea	1.1% 2/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	1.2% 2/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Gastrointestinal disorders Stomach Pain	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
General disorders Flu like symptoms	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
General disorders Nausea	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
General disorders Pain	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Hepatobiliary disorders Gallbladder Pain	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Hepatobiliary disorders Non-Alcoholic Fatty Liver Disease	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Immune system disorders Allergic Reaction	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Bacterial Infection	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Bronchial Infection	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	1.2% 2/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Enterocolitis Infectious	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Food Poisoning	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Kidney Infection	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Laryngitis	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Norovirus	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Sinusitis	1.1% 2/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	1.7% 3/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Skin Papilloma	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.55% 1/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Stomach Virus	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	1.2% 2/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Tooth Infection	0.57% 1/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Unspecified Infection	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.56% 1/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Unspecified Viral Infection	0.00% 0/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.00% 0/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	0.58% 1/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.
Infections and infestations Upper Respiratory Infection	7.4% 13/175 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	9.0% 16/177 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	5.0% 9/181 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.	6.9% 12/173 • up to 78 weeks on study Participants will receive an automated adverse events (AE) survey from REDCap at 9, 18, 26, 35, 44, 52, 61, 70, and 78 weeks. Adverse events can also be brought up by the participant during classes (although unlikely due to limited privacy), maintenance calls, outcome assessments, by email, and in other interactions with the study staff. In such cases, a study team member will follow-up with participants to collect the appropriate adverse event information.