Trial Outcomes & Findings for Direct Measurement of Motor Cortical Responses to tDCS (NCT NCT04759898)
NCT ID: NCT04759898
Last Updated: 2026-05-01
Results Overview
Primary motor cortex (PriMC) beta-band (13-30 Hz) spectral power was measured using subdural electrocorticography (sECoG) in patients with Parkinson's disease undergoing deep brain stimulation surgery. Spectral power was analyzed during the movement preparation phase of a cued arm-reaching task. The outcome represents the change in beta-band spectral power during anodal transcranial direct current stimulation (tDCS) relative to pre-stimulation baseline, averaged across task trials for each participant.
COMPLETED
20 participants
Intraoperative assessment during deep brain stimulation surgery: baseline (pre-tDCS) and during anodal tDCS; change from baseline during movement preparation reported.
2026-05-01
Participant Flow
Participant milestones
| Measure |
Stimulation (Invasive Recording)
Patients with Parkinson's disease undergoing surgery for deep brain stimulation will be studied using electrocorticography combined with transcranial direct current stimulation
|
|---|---|
|
Overall Study
STARTED
|
20
|
|
Overall Study
COMPLETED
|
20
|
|
Overall Study
NOT COMPLETED
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Direct Measurement of Motor Cortical Responses to tDCS
Baseline characteristics by cohort
| Measure |
Stimulation (Invasive Recording)
n=20 Participants
Patients with Parkinson's disease undergoing surgery for deep brain stimulation will be studied using electrocorticography combined with transcranial direct current stimulation
|
|---|---|
|
Age, Continuous
|
65 years
STANDARD_DEVIATION 3 • n=14 Participants
|
|
Sex: Female, Male
Female
|
10 Participants
n=14 Participants
|
|
Sex: Female, Male
Male
|
10 Participants
n=14 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
1 Participants
n=14 Participants
|
|
Race (NIH/OMB)
Asian
|
3 Participants
n=14 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
1 Participants
n=14 Participants
|
|
Race (NIH/OMB)
Black or African American
|
5 Participants
n=14 Participants
|
|
Race (NIH/OMB)
White
|
10 Participants
n=14 Participants
|
|
Race (NIH/OMB)
More than one race
|
0 Participants
n=14 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=14 Participants
|
PRIMARY outcome
Timeframe: Intraoperative assessment during deep brain stimulation surgery: baseline (pre-tDCS) and during anodal tDCS; change from baseline during movement preparation reported.Population: All enrolled participants with analyzable intraoperative sECoG data.
Primary motor cortex (PriMC) beta-band (13-30 Hz) spectral power was measured using subdural electrocorticography (sECoG) in patients with Parkinson's disease undergoing deep brain stimulation surgery. Spectral power was analyzed during the movement preparation phase of a cued arm-reaching task. The outcome represents the change in beta-band spectral power during anodal transcranial direct current stimulation (tDCS) relative to pre-stimulation baseline, averaged across task trials for each participant.
Outcome measures
| Measure |
Stimulation (Invasive Recording)
n=20 Participants
Patients with Parkinson's disease undergoing surgery for deep brain stimulation will be studied using electrocorticography combined with transcranial direct current stimulation
|
|---|---|
|
Change in Primary Motor Cortex Beta-Band Spectral Power During Movement Preparation With Anodal tDCS
|
12 log10(µV²/Hz)
Standard Deviation 3
|
Adverse Events
Stimulation (Invasive Recording)
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place