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Interaction Between Tramadol and Ondansetron

NCT04745273 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2022-11-08

No results posted yet for this study

Summary

In the postoperative period; pain, nausea, and vomiting are undesirable side effects that reduce the patient's comfort and may lead to various complications. Ondansetron is frequently used as an antiemetic and tramadol hydrochloride is used for postoperative analgesia in laparoscopic cholecystectomy. However, some studies have reported that there is a drug interaction between these two drugs and they reduce each other's effects, thus requiring more analgesics in the postoperative period.

The aim of this study is; To evaluate whether ondansetron reduces the analgesic efficacy of tramadol hydrochloride in laparoscopic cholecystectomies.

Conditions

  • Cholecystectomy, Laparoscopic

Interventions

DRUG

Ondansetron 4 MG (Kemoset 4mg)

Ondansetron 4mg (iv) will administer to participants

OTHER

Salin solution

Salin solution 2ml (iv) will administer to participants

Sponsors & Collaborators

  • Acibadem University

    lead OTHER

Principal Investigators

  • Sevgi Bilgen, Assoc. Prof. · Anethesiologist

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-09-02
Primary Completion
2021-06-25
Completion
2021-06-25

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04745273 on ClinicalTrials.gov