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The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU

NCT04737200 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-05-19

No results posted yet for this study

Summary

The purpose of this study is to determine whether modifying the timing of nutrition support from overnight to daytime enhances sleep quality, preserves circadian rhythms, and improves overall inflammation and cardiometabolic profiles in postoperative patients in the cardiac surgical ICU on enteral nutrition.

Conditions

  • Feeding Patterns
  • Sleep
  • Glucose Intolerance

Interventions

DIETARY_SUPPLEMENT

Time-of-day of enteral nutrition provision (daytime first)

Enteral nutrition (tube feeds) will be provided during the daytime followed by nighttime.

DIETARY_SUPPLEMENT

Time-of-day of enteral nutrition provision (nighttime first)

Enteral nutrition (tube feeds) will be provided during the nighttime followed by daytime.

Sponsors & Collaborators

Principal Investigators

  • Hassan S Dashti, Ph.D., R.D. · Massachusetts General Hospital

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-08
Primary Completion
2027-03-31
Completion
2027-03-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04737200 on ClinicalTrials.gov