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Therapeutic Use of Contrast Ultrasound in Acute Coronary Artery Disease

NCT04732091 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 540

Last updated 2023-10-10

No results posted yet for this study

Summary

Preclinical studies have demonstrated that high mechanical index (MI) impulses from a diagnostic ultrasound (DUS) transducer during an intravenous microbubble infusion (sonothrombolysis) can restore epicardial and microvascular flow in acute ST-segment elevation myocardial infarction (STEMI). The investigators propose to demonstrate the clinical effectiveness of sonothrombolysis in multiple centers and in a wide scenario of acute coronary syndromes.

Conditions

  • Acute Myocardial Infarction
  • Unstable Angina

Interventions

PROCEDURE

Therapeutic ultrasound with 20 usec

A custom designed high mechanical index (MI) impulses at 4-20 usec and \>1.0 mechanical index designed for the 1.8 MHz S5-1 transducer

Sponsors & Collaborators

  • University of Nebraska

    collaborator OTHER

  • University of Sao Paulo General Hospital

    lead OTHER

Principal Investigators

  • Wilson Mathias Jr, MD, PhD · Heart Institute - University of São Paulo Medical School

  • Jeane Tsutsui, MD, PhD · Heart Institute - University of São Paulo Medical School

  • Thomas R Porter, MD · University of Nebraska Medical Center, Omaha, NE

Eligibility

Min Age
30 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-02-17
Primary Completion
2024-02-01
Completion
2026-02-01

Countries

  • United States
  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04732091 on ClinicalTrials.gov