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Improving Sleep After TKA Using Mirtazapine and Quetiapine

NCT04728581 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 165

Last updated 2023-06-02

No results posted yet for this study

Summary

Use of mirtazapine and quetiapine for improvement of sleep quality after TKA

Conditions

Interventions

DRUG

Mirtazapine

Use of 3.75mg mirtazapine before lights-out during first 2 weeks after TKA surgery. With insufficient effect on sleep, patients are allowed to increase medication to 7.5mg mirtazapine.

DRUG

Quetiapine

Use of 3.125mg quetiapine before lights-out during first 2 weeks after TKA surgery. With insufficient effect on sleep, patients are allowed to increase medication to 6.25mg mirtazapine.

DRUG

Placebo

a gelatinous capsule without an active ingredient

Sponsors & Collaborators

  • St. Anna Ziekenhuis, Geldrop, Netherlands

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-01-01
Primary Completion
2026-05-01
Completion
2027-01-01

Countries

  • Netherlands

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04728581 on ClinicalTrials.gov