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Biomarkers of Mortality and Morbidity in Children Hospitalized With Fever

NCT04726826 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 2500

Last updated 2021-01-27

No results posted yet for this study

Summary

The objective of this study is to identify clinically informative biomarkers of host defense pathways with potential utility as diagnostic and prognostic tools among children hospitalized with acute febrile illness in a resource-constrained sub-Saharan African setting.

The working hypothesis is that a panel of biomarkers, readily measurable from a peripheral blood sample, may serve as a clinically useful instrument to distinguish between common pediatric causes of fever, predict those children at greatest need of aggressive supportive care and/or adjunctive therapies, and identify those children at greatest risk of mortality. The use of objective and quantitative tools may facilitate the triage and clinical care of febrile children admitted to hospital in the sub-Saharan African context.

Conditions

Interventions

DIAGNOSTIC_TEST

Diagnostic and prognostic biomarkers

Observational study of biomarkers predictive of morbidity and mortality in febrile children

Sponsors & Collaborators

  • University of Toronto

    collaborator OTHER

  • Global Health Uganda LTD

    collaborator OTHER

  • University of Alberta

    lead OTHER

Principal Investigators

  • Michael T Hawkes, MD, PhD · University of Alberta

Eligibility

Min Age
2 Months
Max Age
5 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-02-01
Primary Completion
2013-09-15
Completion
2013-09-15

Countries

  • Uganda

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04726826 on ClinicalTrials.gov