Trial Outcomes & Findings for Esophageal Pressure Measurements During One-lung Ventilation (NCT NCT04725318)

Results Overview

Esophageal pressure during one-lung ventilation in the lateral position at beginning lung collapse as measured by electrical impedance tomography during a decremental PEEP titration

Recruitment status

TERMINATED

Target enrollment

6 participants

Primary outcome timeframe

During one-lung ventilation

Results posted on

2026-02-19

Participant Flow

Participant milestones

Participant milestones
Measure	One-lung Ventilation All participants enrolled in this one-arm study
Overall Study STARTED	6
Overall Study COMPLETED	6
Overall Study NOT COMPLETED	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Esophageal Pressure Measurements During One-lung Ventilation

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	One-lung Ventilation n=6 Participants All participants enrolled in this one-arm study
Age, Continuous	54 years n=4 Participants
Sex: Female, Male Female	3 Participants n=4 Participants
Sex: Female, Male Male	3 Participants n=4 Participants
Race/Ethnicity, Customized Ethnicity · Non-hispanic White	5 Participants n=4 Participants
Race/Ethnicity, Customized Ethnicity · Asian	1 Participants n=4 Participants

PRIMARY outcome

Timeframe: During one-lung ventilation

Population: insufficient data quality in 3 patients

Esophageal pressure during one-lung ventilation in the lateral position at beginning lung collapse as measured by electrical impedance tomography during a decremental PEEP titration

Outcome measures

Outcome measures
Measure	All Patients n=3 Participants All patients enrolled in this one-arm study
Esophageal Pressure at Lung Collapse	0 cmH2O Interval -0.054 to 2.962

SECONDARY outcome

Timeframe: During one-lung ventilation

Esophageal Pressure during one-lung ventilation in the lateral position at airway closure as assessed by pressure-volume curves

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: During two-lung ventilation in the lateral position

Esophageal Pressure during two-lung ventilation in the lateral position at airway closure as assessed by pressure-volume curves

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: During two-lung ventilation in the supine position

Esophageal Pressure during two-lung ventilation in the supine position at airway closure as assessed by pressure-volume curves

Outcome measures

Outcome data not reported

SECONDARY outcome

Timeframe: During one-lung ventilation

PEEP during PEEP titration that provides optimum trade-off between lung collapse and overdistension, as measured by Electrical Impedance Tomography

Outcome measures

Outcome data not reported

Adverse Events

All Patients

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Maximilian Schaefer, MD

Beth Israel Deaconess Medical Center

Phone: 617-632-7034

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place