Hemodynamic Effects During Exercise in Patients With Pulmonary Hypertension Receiving Sildenafil
NCT04706546 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24
Last updated 2023-06-06
Summary
To study hemodynamic effects of Sildenafil during exercise in patients with pulmonary hypertension.
Conditions
- Hypertension, Pulmonary
Interventions
- OTHER
-
Hemodynamic effect of exercise under Sildenafil
Inhalation of room air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise under SIldenafil.
- OTHER
-
Hemodynamic effect of exercise
Inhalation of room air through an altitude simulator ("Altitrainer"), for approx. 1/2 hour given by a facemask, first at rest and then during exercise.
Sponsors & Collaborators
-
University of Zurich
lead OTHER
Principal Investigators
-
Silvia Ulrich, Prof. Dr. · UniversityHospital Zurich, Department of Pulmonology
Study Design
- Allocation
- RANDOMIZED
- Purpose
- OTHER
- Masking
- SINGLE
- Model
- CROSSOVER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-02-01
- Primary Completion
- 2023-05-31
- Completion
- 2023-05-31
Countries
- Switzerland
Study Locations
More Related Trials
-
Effect of Normobaric Hypoxia and Hyperoxia in Patients With Pulmonary Hypertension
NCT03195959 ·Status: COMPLETED
-
Retrospective Data Analysis of Data From the Zurich PH Registry
NCT03198910 ·Status: COMPLETED
-
Acute Exposure of Simulated Hypoxia on Pulmonary Artery Pressure and Right Heart Function (Echo) Under Exercise
NCT03637140 ·Status: COMPLETED ·Phase: NA
-
Hypoxic Pulmonary Vasoconstriction Pilot Study
NCT03733470 ·Status: COMPLETED ·Phase: PHASE4
-
Acute Exposure to High Altitude on Blood and Tissue Oxygenation (ABGA, NIRS)
NCT03600415 ·Status: COMPLETED ·Phase: NA
-
Acute Exposure to High Altitude on Heart Rate and Ventilation During Exercise
NCT03593096 ·Status: COMPLETED ·Phase: NA
-
Vardenafil Inhaled for Pulmonary Arterial Hypertension PRN Phase 2B Study
NCT04266197 ·Status: COMPLETED ·Phase: PHASE2
-
Acute Exposure of Simulated Hypoxia on Blood and Tissue Oxygenation (aBGA, NIRS)
NCT03637114 ·Status: COMPLETED ·Phase: NA
-
Inhaled Nitric Oxide in Pulmonary Embolism
NCT00565253 ·Status: COMPLETED ·Phase: PHASE2
-
Inhaled Nitrite in Subjects With Pulmonary Hypertension
NCT01431313 ·Status: COMPLETED ·Phase: PHASE2
-
Acute Exposure of High Altitude on Cardiac Output
NCT03637218 ·Status: COMPLETED ·Phase: NA
-
Effect of Long-term Oxygen Therapy on Exercise Capacity and Quality of Life in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension
NCT01884012 ·Status: COMPLETED ·Phase: PHASE3
-
Safety and Efficacy of Inhaled Treprostinil in Patients With PAH
NCT01557647 ·Status: WITHDRAWN ·Phase: PHASE3
-
Acute Exposure to High Altitude on Exercise Capacity
NCT03637153 ·Status: COMPLETED ·Phase: NA
-
Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo) Under Exercise
NCT03637179 ·Status: COMPLETED ·Phase: NA
-
PAH Exercise Study
NCT06941441 ·Status: RECRUITING ·Phase: PHASE3
-
Clinical Investigation Into Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH)
NCT00147199 ·Status: COMPLETED ·Phase: PHASE3
-
Acute Exposure of Simulated Hypoxia on Cardiac Output
NCT03574675 ·Status: COMPLETED ·Phase: NA
-
A Study to Evaluate the Use of Bosentan in Patients With Exercise Induced Pulmonary Arterial Hypertension Associated With Connective Tissue Disease
NCT00864201 ·Status: UNKNOWN ·Phase: PHASE3
-
Dose-Finding, Safety, Pharmacodynamic Effect Study of Sodium Nitrite Inhalation Solution in Normal, Healthy Volunteers
NCT00814645 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)
NCT03496623 ·Status: TERMINATED ·Phase: PHASE3
-
Study of BSF 208075 Evaluating Exercise Capacity in Patients With Pulmonary Arterial Hypertension
NCT00046319 ·Status: COMPLETED ·Phase: PHASE2
-
Acute Exposure to High Altitude on Symptoms
NCT03593005 ·Status: COMPLETED ·Phase: NA
-
Safety, Tolerability, and PK Parameters of Sodium Nitrite Inhalation Solution in Healthy Subjects
NCT01409122 ·Status: COMPLETED ·Phase: PHASE1
-
HA Residents With PVD, Pulmonary Artery Pressure (PAP) Assessed at HA (2840m) With and Without Supplemental Oxygen Therapy (SOT)
NCT06084559 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA