Study of the Immunological and Virological Response of Patients With COVID-19 and Presenting an Asymptomatic or Pauci-symptomatic Form (AMBUCOV)

Summary

The purpose of this study is to describe the immunological and virological response of patients infected with CoV-2-SARS and presenting an asymptomatic or mildly symptomatic form, in particular the innate and adaptive response as well as the virological clearance kinetics.

The research hypothesis is that patients with an ambulatory form of SARS-CoV-2 infection, whether asymptomatic or mildly symptomatic, are able to mount an innate and adaptive immunological response capable of rapidly clearing the virus, in contrast to severe forms in which an early deficit of type 1 IFN response has been demonstrated, possibly responsible for a defect in the control of viral replication in the blood.

Conditions

• Covid19
• SARS-CoV-2

Interventions

DIAGNOSTIC_TEST

Blood count

Blood count at each visit

DIAGNOSTIC_TEST

Blood collection

Blood collection to understanding of the immunological profile at each visit

DIAGNOSTIC_TEST

Nasopharyngeal swab

Research of SARS-CoV-2 infection in nasopharyngeal swab by RT-PCR at day 8 and day 15

DIAGNOSTIC_TEST

Saliva samples

Research of SARS-CoV-2 infection in saliva samples at each visit (excepted inclusion)

DIAGNOSTIC_TEST

Faeces samples

Research of SARS-CoV-2 infection in faeces samples at day 3, day 15 and day 90

GENETIC

Genetic blood collection

Collection to further research at each visit

OTHER

Data collection

Demographics, symptoms, biological constants

Sponsors & Collaborators

• Fonds IMMUNOV

  collaborator UNKNOWN

• URC-CIC Paris Descartes Necker Cochin

  collaborator OTHER

• Assistance Publique - Hôpitaux de Paris

  lead OTHER

Principal Investigators

• Solen KERNEIS, Doctor · Assistance Publique - Hôpitaux de Paris

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-02-05

Primary Completion

2021-09-15

Completion

2021-09-15

Countries

• France

Study Locations