Retrospective Study Assessing the Effect of Avapritinib Versus Best Available Therapy in Patients With AdvSM
NCT04695431 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 317
Last updated 2022-01-10
Summary
BLU-285-2405 is a multi-center, synthetic control, observational and retrospective study designed to compare clinical outcomes for avapritinib compared with best available therapy for patients with AdvSM.
Conditions
- Advanced Systemic Mastocytosis
- Aggressive Systemic Mastocytosis
- Systemic Mastocytosis With an Associated Hematological Neoplasm
- Mast Cell Leukemia
Sponsors & Collaborators
-
Analysis Group, Inc.
collaborator INDUSTRY -
Blueprint Medicines Corporation
lead INDUSTRY
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-12-02
- Primary Completion
- 2021-10-04
- Completion
- 2021-10-04
Countries
- United States
- Austria
- Germany
- Spain
- United Kingdom
Study Locations
More Related Trials
-
Pacritinib Versus Best Available Therapy to Treat Patients With Myelofibrosis and Thrombocytopenia
NCT02055781 ·Status: TERMINATED ·Phase: PHASE3
-
Ravulizumab in Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplant
NCT04543591 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Evaluate Efficacy and Safety of AVTX-803 in Patients With Leukocyte Adhesion Deficiency Type II
NCT05462587 ·Status: RECRUITING ·Phase: PHASE3
-
Safety and Treatment Satisfaction in Adults With Chronic ITP After Switching to Avatrombopag From Eltrombopag or Romiplostim
NCT04638829 ·Status: COMPLETED ·Phase: PHASE4
-
Study of Ravulizumab in Pediatric Participants With HSCT-TMA
NCT04557735 ·Status: COMPLETED ·Phase: PHASE3
-
The Safety and Efficacy Study of Avatrombopag Switch in TPO-RA Refractory AA
NCT05518331 ·Status: RECRUITING ·Phase: NA
-
Avatrombopag vs. Placebo for CIT in GI Malignancies
NCT05772546 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Efficacy and Safety of Avatrombopag vs. Avatrombopag Combined With rhTPO in the Treatment of SAA
NCT06254287 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Efficacy and Safety of Avatrombopag in Cancer Patients With Thrombocytopenia
NCT04896528 ·Status: UNKNOWN ·Phase: PHASE2
-
APG-2575 Single Agent or in Combination With Ibrutinib or Rituximab in Patients With Waldenström Macroglobulinemia
NCT04260217 ·Status: COMPLETED ·Phase: PHASE1
-
Avatrombopag for Chemotherapy-induced Thrombocytopenia
NCT05218226 ·Status: RECRUITING ·Phase: PHASE2
-
A Study of Pirtobrutinib, Venetoclax, and Rituximab in People With Waldenström's Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (LPL)
NCT07231952 ·Status: RECRUITING ·Phase: PHASE2
-
Avatrombopag in the Treatment of Primary Immune Thrombocytopenia(ITP)
NCT04949009 ·Status: UNKNOWN
-
Eltrombopag in Combination With Rabbit Anti-thymocyte Globulin/Cyclosporine A in Naive Aplastic Anemia (AA) Subjects
NCT02404025 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Assess the Ability of Eltrombopag to Induce Sustained Response Off Treatment in Subjects With ITP
NCT03524612 ·Status: COMPLETED ·Phase: PHASE2
-
Phase 2, Parallel Group, Rollover Study of AKR-501 in Patients With ChronicITP Who Completed 28 Days of Study Treatment in Protocol 501-CL-003
NCT00625443 ·Status: COMPLETED ·Phase: PHASE2
-
Caplacizumab and Immunosuppressive Therapy Without Firstline Therapeutic Plasma Exchange in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura
NCT05468320 ·Status: COMPLETED ·Phase: PHASE3
-
A PHASE II TRIAL AIMING TO INVESTIGATE THE SAFETY AND CLINICAL ACTIVITY OF BELANTAMAB MAFODOTIN IN ADULT PATIENTS WITH PRIMARY IMMUNE THROMBOCYTOPENIA PREVIOUSLY TREATED WITH A THROMBOPOIETIN RECEPTOR AGONIST AND/OR RITUXIMAB AFTER CORTICOSTEROID FIRST-LINE THERAPY
NCT07019545 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Study of Pegcetacoplan for Patients With Transplant-associated Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplantation
NCT05148299 ·Status: COMPLETED ·Phase: PHASE2
-
An Observational, Multicenter Study to Evaluate the Use and Effectiveness of Doptelet® in Patients With ITP
NCT04943042 ·Status: COMPLETED
-
Efficacy of a Personalized Caplacizumab Regimen Based on ADAMTS13 Activity Monitoring in Adult aTTP
NCT04720261 ·Status: TERMINATED ·Phase: PHASE2
-
Avatrombopag Usage in NSAA
NCT04728789 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
Rituximab and Prednisone as First-Line Therapy in Treating Patients With Immune Thrombocytopenic Purpura
NCT00486421 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Open-Label Study to Evaluate the Safety and Efficacy of Avatrombopag and Remission Rates in Adults With ITP of ≤6 Months
NCT05046327 ·Status: WITHDRAWN ·Phase: PHASE3
-
Clinical Trial of Aplidin® in Patients With Primary Myelofibrosis
NCT01149681 ·Status: COMPLETED ·Phase: PHASE2