MedTrace Logo

Comparing TAP Blocks Bupivacaine, and Placebo for Plane

NCT04685876 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 285

Last updated 2025-08-27

Study results available
· View outcomes & findings →

Summary

The study will prospectively compare the analgesic efficacy of TAP blocks with liposomal bupivacaine, plain bupivacaine, and placebo in patients who are scheduled for major abdominal surgery. The primary aim is to assess the duration of the local analgesia (determined by pinprick and cold) in all four quadrants. Comparing opioid consumption and pain scores is a secondary aim. All aims will be assessed over 72 hours or the duration of hospitalization if shorter.

Conditions

  • Abdominal Surgery

Interventions

DRUG

Liposomal bupivacaine

4-quadrant TAP block with liposomal bupivacaine

DRUG

Plain bupivacaine

4-quadrant TAP block with plain bupivacaine

DRUG

Normal saline

placebo (normal saline).

Sponsors & Collaborators

  • Edward Mascha

    lead OTHER

Principal Investigators

  • Alparslan Turan, MD · The Cleveland Clinic

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-04
Primary Completion
2024-02-20
Completion
2024-02-20
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04685876 on ClinicalTrials.gov