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Neutrophil to Lymphocyte Ratio as a Predictor of Complicated Acute Diverticulitis

NCT04663490 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 325

Last updated 2020-12-11

No results posted yet for this study

Summary

Introduction: Various biomarkers have been studied to predict the severity of acute diverticulitis (AD), such as the leukocyte count and CRP, which are useful but lack sufficient sensitivity. The neutrophil-lymphocyte ratio (NLR) has been identified as a new inflammatory biomarker in several abdominal pathologies. However, few studies determine its association with the severity of AD. The objective of the present study was to determine the utility and diagnostic precision of NLR in complicated acute diverticulitis (cAD).

Material and methods: Descriptive, retrospective and analytical study. Patients older than 18 years with a diagnosis of AD were included, from 2013 - 2018. Demographic variables, days of hospitalization, leukocyte count, neutrophils, lymphocytes, ESR, CRP, and NLR were analyzed. The sensitivity and specificity for the diagnosis of cAD were determined using ROC curves.

Conditions

  • Acute Diverticulitis

Interventions

DIAGNOSTIC_TEST

Neutrophil to Lymphocyte Ratio

Zahorec et al. identified the neutrophil-lymphocyte ratio (NLR) as an inflammation marker in critical patients, defining as the absolute neutrophil count divided by the absolute lymphocyte count

Sponsors & Collaborators

  • Clinica Universitaria Reina Fabiola, Universidad Catolica de Cordoba

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
92 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-01-01
Primary Completion
2018-01-01
Completion
2020-01-01

Countries

  • Argentina

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04663490 on ClinicalTrials.gov