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Central Programming in Patients With a Bionic Hand After Traumatic Brachial Plexus Injury

NCT04649749 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 11

Last updated 2023-09-28

No results posted yet for this study

Summary

Traumatic brachial plexus lesions may lead to permanent impairment of hand function despite brachial plexus surgery. In selected cases the affected forearm can be amputated and replaced by a bionic hand. It is unclear how cortical activation patterns change after the injury and after acquisition of the hand prosthesis considering the complex changes in sensory and motor feedback. The aim of the study is to measure cortical activity with fMRI during actual and imagery movements with the affected and healthy arm in a group of patients after traumatic brachial plexus injury and a group in whom this was followed by replacement with a bionic hand. In this prospective study three groups of patients will participate: 1) 3 adult patients with a traumatic brachial plexus lesion eligible for a bionic arm but prior to its acquisition, 2) 3 patients with a traumatic brachial plexus lesion who have acquired the bionic arm already, and 3) 10 healthy subjects. The investigators will measure cortical activity using fMRI BOLD tasks of closing the hand and motor imagery of this movement. Cortical activity will be compared between the three groups. Additionally, regional gray matter volume, resting-state, and DTI networks will be studied. Written informed consent will be provided prior to the investigation. The complete examination has a duration of approximately 45 minutes.

Conditions

  • Brachial Plexus Neuropathies
  • Traumatic Brachial Plexus Lesion
  • Bionic Hand Reconstruction

Interventions

DIAGNOSTIC_TEST

MRI

MRI scan

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Oskar Aszmann, prof. dr. · Medical University of Vienna

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-10-01
Primary Completion
2022-09-01
Completion
2022-09-01

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04649749 on ClinicalTrials.gov