Individualized Titration of Biologics in Severe Asthma
NCT04648761 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 75
Last updated 2023-01-18
Summary
OPTIMAL is a non-inferiority, open label randomized clinical trial thats investigates a titration algorithm for anti IL 5 biologics in severe asthma.
Conditions
Interventions
- BIOLOGICAL
-
OPTIMAL algorithm
The OPTIMAL algorithm titrates anti IL 5 treatment by addjusting the intervals between injections by FEV1, blood eosinophils and exacerbations.
Sponsors & Collaborators
-
Bispebjerg Hospital
lead OTHER
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-01-01
- Primary Completion
- 2022-10-01
- Completion
- 2023-10-01
Countries
- Denmark
Study Locations
More Related Trials
-
Longitudinal Cohort Study in Participants With Severe Asthma to Assess Biomarkers
NCT02537691 ·Status: COMPLETED ·Phase: PHASE4
-
Omalizumab in Adult and Adolescent Patients With Severe Persistent Allergic Asthma
NCT00264849 ·Status: COMPLETED ·Phase: PHASE4
-
Evaluation of Safety and Tolerability of BI 894416 in Patients With Mild Asthma
NCT03971539 ·Status: COMPLETED ·Phase: PHASE1
-
Clinical Pharmacology Study of CHF1535 pMDI 50/6 µg Versus The Free Combination In Asthmatic Children 5-11 Years Old
NCT01848769 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Tolerability of Omalizumab in Patients With Mild to Moderate Asthma
NCT00546143 ·Status: COMPLETED ·Phase: PHASE4
-
Real Life Effectiveness in Patients With Not Optimally Controlled Asthma
NCT00784953 ·Status: COMPLETED
-
TRIple in asthMA With uncontRolled pAtient on Medium streNgth of ICS + LABA
NCT02676076 ·Status: COMPLETED ·Phase: PHASE3
-
Roflumilast Plus Montelukast in Adults With Severe Asthma
NCT01765192 ·Status: COMPLETED ·Phase: PHASE2
-
Cross-sectional Study for Identification and Description of Severe Asthma Patients
NCT02293265 ·Status: COMPLETED ·Phase: PHASE3
-
A Pharmaceopidemiological Study in Patients Who Use Symbicort SMART
NCT00503061 ·Status: COMPLETED
-
REALL: A Retrospective Observational Study to Compare the Effectiveness and Cost-Effectiveness Between Different Step-3 Asthma Treatment Strategies
NCT00628563 ·Status: COMPLETED
-
A Clinical Trial to Study the Effects of Revamilast in Patients With Chronic Persistent Asthma
NCT01436890 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Tolerability of Maintenance Treatment With Asmanex Twisthaler Versus Placebo in Mild/Moderate Persistent Asthmatics (Study P04654)(TERMINATED)
NCT00442351 ·Status: TERMINATED ·Phase: PHASE4
-
Comparative Study of the Efficacy of Biologics vs Usual Treatment on OCS Reduction for Severe Asthma Patients Using Health Insurance Claim Database
NCT05136547 ·Status: COMPLETED
-
Controller Medications in the Management of Bronchial Asthma
NCT01055041 ·Status: COMPLETED ·Phase: NA
-
Concentrations of Salmeterol in Blood and Urine
NCT00914901 ·Status: UNKNOWN ·Phase: PHASE4
-
Safety and Tolerability of Omalizumab in Poorly Controlled Moderate to Severe Asthma Patients
NCT00482508 ·Status: COMPLETED ·Phase: PHASE3
-
Safety and Tolerability of Ciclesonide and Formoterol Fumarate Inhaled Once Daily in Patients With Asthma (18 to 75 y) (BY9010/M1-506)
NCT00314509 ·Status: COMPLETED ·Phase: PHASE2
-
Titratable Dosing in Moderate to Severe Asthmatics
NCT00651768 ·Status: COMPLETED ·Phase: PHASE3
-
Similarities and Differences of Biological Therapies for Severe Asthma.
NCT04665141 ·Status: UNKNOWN
-
Study of an Approved Drug in Patients With Asthma (0476-289)(COMPLETED)
NCT00092144 ·Status: COMPLETED ·Phase: PHASE3
-
An Observational Study to Investigate How Patients Experience the Ability to Adjust Their Asthma Maintenance Medication
NCT00577265 ·Status: COMPLETED
-
Effect of Biologicals on Alternative Functions of Eosinophils in Severe Asthma
NCT04520165 ·Status: ACTIVE_NOT_RECRUITING
-
Down-titration of Steroids in Patients With Difficult Asthma With no Bronchial Hyperreactivity
NCT03321877 ·Status: COMPLETED ·Phase: NA
-
A Phase II Study to Evaluate the Efficacy, Safety and Tolerability of AZD5069 in Patients With Uncontrolled Persistent Asthma.
NCT01704495 ·Status: COMPLETED ·Phase: PHASE2