Trial Outcomes & Findings for Increasing Treatment Efficacy Using SMART Methods for Personalizing Care (NCT NCT04642898)

Last Updated: 2025-07-30

Results Overview

Clinical severity will be measured using the Diagnostic Interview for Anxiety, Mood, and Obsessive Compulsive and Related Neuropsychiatric Disorders (DIAMOND) dimensional clinician ratings. Scores range from 1-7; higher scores indicate greater severity. Negative scores indicate symptom improvement.

Recruitment status

COMPLETED

Study phase

Target enrollment

61 participants

Primary outcome timeframe

Baseline to 6 weeks (Brief Intervention), Baseline to 12 weeks (Full Intervention

Results posted on

2025-07-30

Participant Flow

Participant milestones

Participant milestones
Measure	Standard Group, Brief Intervention Participants in this group will receive 6 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Standard Group, Full Intervention Participants in this group will receive 12 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Capitalization Group, Brief Intervention Participants in this group will receive 6 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Capitalization Group, Full Intervention Participants in this group will receive 12 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Compensation Group, Brief Intervention Participants in this group will receive 6 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.	Compensation Group, Full Intervention Participants in this group will receive 12 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.
Overall Study STARTED	11	10	10	10	10	10
Overall Study COMPLETED	8	6	6	2	7	2
Overall Study NOT COMPLETED	3	4	4	8	3	8

Reasons for withdrawal

Reasons for withdrawal
Measure	Standard Group, Brief Intervention Participants in this group will receive 6 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Standard Group, Full Intervention Participants in this group will receive 12 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Capitalization Group, Brief Intervention Participants in this group will receive 6 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Capitalization Group, Full Intervention Participants in this group will receive 12 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Compensation Group, Brief Intervention Participants in this group will receive 6 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.	Compensation Group, Full Intervention Participants in this group will receive 12 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.
Overall Study Withdrawal by Subject	2	4	4	6	2	6
Overall Study Lost to Follow-up	0	0	0	2	0	1
Overall Study Therapist left trial before patient completed treatment	1	0	0	0	0	1
Overall Study Ineligible due to conflict of interest with therapist	0	0	0	0	1	0

Baseline Characteristics

1 participant in the standard group, full intervention did not complete the demographic info survey and 1 participant in the compensation group, brief intervention did not report their age

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Standard Group, Brief Intervention n=11 Participants Participants in this group will receive 6 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Standard Group, Full Intervention n=10 Participants Participants in this group will receive 12 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Capitalization Group, Brief Intervention n=10 Participants Participants in this group will receive 6 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Capitalization Group, Full Intervention n=10 Participants Participants in this group will receive 12 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Compensation Group, Brief Intervention n=10 Participants Participants in this group will receive 6 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.	Compensation Group, Full Intervention n=10 Participants Participants in this group will receive 12 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.	Total n=61 Participants Total of all reporting groups
Age, Continuous	33.36 years STANDARD_DEVIATION 8.87 • n=11 Participants • 1 participant in the standard group, full intervention did not complete the demographic info survey and 1 participant in the compensation group, brief intervention did not report their age	39.67 years STANDARD_DEVIATION 14.55 • n=9 Participants • 1 participant in the standard group, full intervention did not complete the demographic info survey and 1 participant in the compensation group, brief intervention did not report their age	44.60 years STANDARD_DEVIATION 15.10 • n=10 Participants • 1 participant in the standard group, full intervention did not complete the demographic info survey and 1 participant in the compensation group, brief intervention did not report their age	36.10 years STANDARD_DEVIATION 10.84 • n=10 Participants • 1 participant in the standard group, full intervention did not complete the demographic info survey and 1 participant in the compensation group, brief intervention did not report their age	36.78 years STANDARD_DEVIATION 10.84 • n=9 Participants • 1 participant in the standard group, full intervention did not complete the demographic info survey and 1 participant in the compensation group, brief intervention did not report their age	37.50 years STANDARD_DEVIATION 13.19 • n=10 Participants • 1 participant in the standard group, full intervention did not complete the demographic info survey and 1 participant in the compensation group, brief intervention did not report their age	37.92 years STANDARD_DEVIATION 12.35 • n=59 Participants • 1 participant in the standard group, full intervention did not complete the demographic info survey and 1 participant in the compensation group, brief intervention did not report their age
Sex: Female, Male Female	9 Participants n=11 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	6 Participants n=9 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	8 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	8 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	8 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	6 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	45 Participants n=60 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form
Sex: Female, Male Male	2 Participants n=11 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	3 Participants n=9 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	2 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	2 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	2 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	4 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	15 Participants n=60 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form
Ethnicity (NIH/OMB) Hispanic or Latino	1 Participants n=11 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	0 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	0 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	1 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	0 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	0 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	2 Participants n=61 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form
Ethnicity (NIH/OMB) Not Hispanic or Latino	10 Participants n=11 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	9 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	10 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	9 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	10 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	10 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	58 Participants n=61 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=11 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	1 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	0 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	0 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	0 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	0 Participants n=10 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form	1 Participants n=61 Participants • 1 participant in the standard group, full intervention did not fill out the demographics form
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=11 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=61 Participants
Race (NIH/OMB) Asian	0 Participants n=11 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	1 Participants n=10 Participants	0 Participants n=10 Participants	1 Participants n=61 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=11 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=61 Participants
Race (NIH/OMB) Black or African American	0 Participants n=11 Participants	2 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	1 Participants n=10 Participants	3 Participants n=61 Participants
Race (NIH/OMB) White	9 Participants n=11 Participants	7 Participants n=10 Participants	10 Participants n=10 Participants	9 Participants n=10 Participants	9 Participants n=10 Participants	9 Participants n=10 Participants	53 Participants n=61 Participants
Race (NIH/OMB) More than one race	1 Participants n=11 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	1 Participants n=61 Participants
Race (NIH/OMB) Unknown or Not Reported	1 Participants n=11 Participants	1 Participants n=10 Participants	0 Participants n=10 Participants	1 Participants n=10 Participants	0 Participants n=10 Participants	0 Participants n=10 Participants	3 Participants n=61 Participants
Region of Enrollment United States	11 participants n=11 Participants	10 participants n=10 Participants	10 participants n=10 Participants	10 participants n=10 Participants	10 participants n=10 Participants	10 participants n=10 Participants	61 participants n=61 Participants

PRIMARY outcome

Timeframe: Baseline to 6 weeks (Brief Intervention), Baseline to 12 weeks (Full Intervention

Population: Outcomes for participants in brief intervention groups will be the difference in clinical severity at assessments before and after 6 sessions of treatment. Outcomes for participants in full intervention groups will be the difference in clinical severity at assessments before and after 12 sessions of treatment. Participants who completed their pre- and post-treatment clinician assessment meetings were analyzed.

Outcome measures

Outcome measures
Measure	Standard Group, Brief Intervention n=10 Participants Participants in this group will receive 6 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Standard Group, Full Intervention n=7 Participants Participants in this group will receive 12 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Capitalization Group, Brief Intervention n=7 Participants Participants in this group will receive 6 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Capitalization Group, Full Intervention n=2 Participants Participants in this group will receive 12 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Compensation Group, Brief Intervention n=7 Participants Participants in this group will receive 6 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.	Compensation Group, Full Intervention n=3 Participants Participants in this group will receive 12 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.
Change in Clinical Severity From Baseline to 6 Weeks (Brief Intervention) or 12 Weeks (Full Intervention)	-2.40 score on a scale Standard Deviation 1.26	-2.86 score on a scale Standard Deviation 1.46	-2.71 score on a scale Standard Deviation 1.25	-2.00 score on a scale Standard Deviation 1.14	-3.00 score on a scale Standard Deviation 1.15	-3.33 score on a scale Standard Deviation .58

PRIMARY outcome

Timeframe: Baseline to 6 weeks (Brief Intervention), Baseline to 12 weeks (Full Intervention)

Population: Outcomes for participants in brief intervention groups is the difference in self-reported anxiety symptoms before and after 6 treatment sessions and outcomes for participants in full intervention groups is the difference in scores before and after 12 sessions. Participants who completed the pre- and post-treatment assessment questionnaires were analyzed. Several participants completed the post-treatment clinician meeting but not the questionnaires, creating a disparity in sample across outcomes

Anxiety symptoms will be measured using the Overall Anxiety Severity and Interference Scale (OASIS). This is a self-report measure in which scores range from 0-20; higher scores indicate more severe anxiety symptoms. Negative scores indicate symptom improvement. assessed at baseline and weekly for 6 or 12 weeks, change from baseline after 6 sessions (6 weeks) and after 12 sessions (12 weeks) are being reported

Outcome measures

Outcome measures
Measure	Standard Group, Brief Intervention n=9 Participants Participants in this group will receive 6 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Standard Group, Full Intervention n=7 Participants Participants in this group will receive 12 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Capitalization Group, Brief Intervention n=5 Participants Participants in this group will receive 6 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Capitalization Group, Full Intervention n=1 Participants Participants in this group will receive 12 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Compensation Group, Brief Intervention n=6 Participants Participants in this group will receive 6 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.	Compensation Group, Full Intervention n=2 Participants Participants in this group will receive 12 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.
Change in Self-Reported Anxiety Symptoms From Baseline to 6 Weeks (Brief Intervention) or 12 Weeks (Full Intervention)	-2.56 score on a scale Standard Error 2.40	-1.57 score on a scale Standard Error 4.69	-2.00 score on a scale Standard Error 2.74	-2.00 score on a scale Standard Error 0	-3.33 score on a scale Standard Error 2.66	-7.50 score on a scale Standard Error .71

PRIMARY outcome

Timeframe: Baseline to 6 weeks (Brief Intervention), Baseline to 12 weeks (Full Intervention)

Population: Outcomes for participants in brief intervention groups is the difference in self-reported symptoms before and after 6 treatment sessions and outcomes for participants in full intervention groups is the difference in scores before and after 12 sessions. Participants who completed the pre- and post-treatment assessment questionnaires were analyzed. Several participants completed the post-treatment clinician meeting but not the questionnaires, creating a disparity in sample across outcomes

Depressive symptoms will be measured using the Overall Depression Severity and Interference Scale (ODSIS). This is a self-report measure in which scores range from 0-20; higher scores indicate more severe anxiety symptoms. Negative scores indicate symptom improvement. assessed at baseline and weekly for 6 or 12 weeks, change from baseline after 6 sessions (6 weeks) and after 12 sessions (12 weeks) are being reported

Outcome measures

Outcome measures
Measure	Standard Group, Brief Intervention n=9 Participants Participants in this group will receive 6 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Standard Group, Full Intervention n=7 Participants Participants in this group will receive 12 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Capitalization Group, Brief Intervention n=5 Participants Participants in this group will receive 6 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Capitalization Group, Full Intervention n=1 Participants Participants in this group will receive 12 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Compensation Group, Brief Intervention n=6 Participants Participants in this group will receive 6 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.	Compensation Group, Full Intervention n=2 Participants Participants in this group will receive 12 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.
Change in Self-Reported Depressive Symptoms From Baseline to 6 Weeks (Brief Intervention) or 12 Weeks (Full Intervention)	0 score on a scale Standard Deviation 4.58	-1.57 score on a scale Standard Deviation 6.32	-1.20 score on a scale Standard Deviation 3.56	-4.00 score on a scale Standard Deviation 0	-1.67 score on a scale Standard Deviation 4.41	-3.00 score on a scale Standard Deviation 1.41

PRIMARY outcome

Timeframe: Baseline to 6 weeks (Brief Intervention), Baseline to 12 weeks (Full Intervention)

Aversive reactions to emotions will be measured using the distress aversion subscale of the Multidimensional Experiential Avoidance Questionnaire (MEAQ). This is a self-report measure in which scores range from 13-78; higher scores indicate greater negative reactions to emotional experiences. Negative scores indicate symptom improvement. assessed at baseline and weekly for 6 or 12 weeks, change from baseline after 6 sessions (6 weeks) and after 12 sessions (12 weeks) are being reported

Outcome measures

Outcome measures
Measure	Standard Group, Brief Intervention n=9 Participants Participants in this group will receive 6 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Standard Group, Full Intervention n=7 Participants Participants in this group will receive 12 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Capitalization Group, Brief Intervention n=5 Participants Participants in this group will receive 6 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Capitalization Group, Full Intervention n=1 Participants Participants in this group will receive 12 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Compensation Group, Brief Intervention n=6 Participants Participants in this group will receive 6 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.	Compensation Group, Full Intervention n=2 Participants Participants in this group will receive 12 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.
Change in Self-Reported Aversive Reactions to Emotions From Baseline to 6 Weeks (Brief Intervention) or 12 Weeks (Full Intervention)	-4.44 score on a scale Standard Deviation 9.54	-7.14 score on a scale Standard Deviation 6.79	-3.40 score on a scale Standard Deviation 8.65	-2.00 score on a scale Standard Deviation 0	-6.83 score on a scale Standard Deviation 8.15	-18.50 score on a scale Standard Deviation 6.36

PRIMARY outcome

Timeframe: Baseline to 6 weeks (Brief Intervention), Baseline to 12 weeks (Full Intervention)

Population: Participants who completed the pre- and post-treatment clinician assessment meetings. Several participants completed the post-treatment clinician assessment, but did not complete the associated questionnaire batteries, which is why there is a disparity in the number of participants analyzed across outcome measures.

Clinician-rated anxiety symptoms will be measured using the Hamilton Rating Scale for Anxiety Symptoms. Scores range from 0-56; higher scores indicate greater severity. Negative scores indicate symptom improvement. Outcomes for participants in brief intervention groups is the difference in clinician rated symptom scores before and after 6 treatment sessions and outcomes for participants in full intervention groups is the difference in clinician rated symptom scores before and after 12 sessions.

Outcome measures

Outcome measures
Measure	Standard Group, Brief Intervention n=10 Participants Participants in this group will receive 6 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Standard Group, Full Intervention n=7 Participants Participants in this group will receive 12 sessions of treatment in accordance with the standard, published Unified Protocol (UP) manual. Standard UP Treatment: Participants will receive treatment modules sequenced in accordance with the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al 2011; 2018).	Capitalization Group, Brief Intervention n=7 Participants Participants in this group will receive 6 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Capitalization Group, Full Intervention n=2 Participants Participants in this group will receive 12 sessions of treatment organized to prioritize skills that capitalize on patient strengths. Capitalization UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that capitalize on patient strengths.	Compensation Group, Brief Intervention n=7 Participants Participants in this group will receive 6 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.	Compensation Group, Full Intervention n=3 Participants Participants in this group will receive 12 sessions of treatment organized to prioritize skills that compensate for patient weaknesses. Compensation UP Treatment: Participants will receive Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) treatment modules organized to prioritize skills that compensate for patient weaknesses.
Change in Clinician-Rated Anxiety Symptoms From Baseline to 6 Weeks (Brief Intervention) or 12 Weeks (Full Intervention)	-3.6 score on a scale Standard Deviation 6.99	-2.57 score on a scale Standard Deviation 7.5	-8.29 score on a scale Standard Deviation 8.53	-8.50 score on a scale Standard Deviation 7.78	-6.00 score on a scale Standard Deviation 4.90	-5.00 score on a scale Standard Deviation 8.19

PRIMARY outcome

Timeframe: Baseline to 6 weeks (Brief Intervention), Baseline to 12 weeks (Full Intervention)

Clinician-rated depressive symptoms will be measured using the Hamilton Rating Scale for Depressive Symptoms. Scores range from 0-68; higher scores indicate greater severity. Negative scores indicate symptom improvement. Outcomes for participants in brief intervention groups is the difference in Clinician-Rated symptom scores before and after 6 treatment sessions and outcomes for participants in full intervention groups is the difference in Clinician-Rated symptom scores before and after 12 sessions.