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Acute Pancreatitis and Thrombosis (PATHRO)

NCT04642794 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 51

Last updated 2024-07-11

No results posted yet for this study

Summary

Severe acute pancreatitis (AP) is a pathology with high morbidity and mortality. Portosplenomesenteric vein thrombosis is a well-known local complication of AP with a variable incidence, which can reach up to 50% in case of severe AP. However, there is no specific recommendation regarding the management of Portosplenomesenteric vein thrombosis. By analogy to all venous thrombosis, the European Society of Gastroenterology recommends curative anticoagulation. However, the efficacy of curative anticoagulation has never been evaluated by prospective studies. In addition, bleeding complications during AP occur in approximately 10% of patients and are associated with a poor prognosis.

The investigators wish to conduct an observational multi-center study with epidemiologic aims, including all patients admitted for AP and with a diagnosis of portosplenomesenteric vein thrombosis. The aim of this study is to evaluate the therapeutic management of these patients, the efficacy and safety of anticoagulant treatment for the treatment of Portosplenomesenteric vein thrombosis, and their outcomes.

Conditions

  • Acute Necrotizing Pancreatitis
  • Portosplenomesenteric Venous Thrombosis

Interventions

OTHER

observational study

patients admitted for AP with portosplenomesenteric vein thrombosis.

Sponsors & Collaborators

  • Nantes University Hospital

    lead OTHER

Principal Investigators

  • GARRET Charlotte, MD · University hospital of Nantes

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-01
Primary Completion
2022-07-15
Completion
2022-07-15

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04642794 on ClinicalTrials.gov