Metabotyping of Overweight and Obese Children

Summary

Today's children are increasingly facing metabolic-related health issues, among which the worldwide prevalence of overweight and obesity is rising at an alarming pace. Childhood obesity is associated with the early onset of chronic diseases including an emergence of prediabetes and diabetes mellitus type 2. The decline of insulin sensitivity already years before puberty, exposes children to long- term complications prior the appearance of clinical symptoms and time of diagnosis. The shortened life expectancy and large economic burden imposed underlines the need for the identification of metabotypes at risk at an early stage. One's genetics, microbial gut composition and every aspect of the environment in which children are raised have been implicated in diet-related obesity rendering metabolomics a very powerful tool towards precision medicine. Yet, the excellence of stool in reflecting the intertwining thereof is completely unexplored for pediatric purposes, whereas blood sampling causing pain and stress for child and parent only captures a narrow fraction of the metabolome. As such, rectal sampling using a customised medical swab for optimal gut metabolome coverage is envisioned. Ambient laser desorption ionisation will be hyphenated to high-resolution mass spectrometry-based metabolomics to provide a framework for elucidating predictive and/or prognostic biomarkers for ever-increasing pediatric metabolic diseases such as obesity and (pre)diabetes.

Conditions

• Metabolic Disease
• Obesity, Infant

Interventions

DEVICE

MetaSAMP

Rectal Sampler

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven

  collaborator OTHER

• Universitair Ziekenhuis Brussel

  collaborator OTHER

• Algemeen Ziekenhuis Maria Middelares

  collaborator OTHER

• AZ Jan Palfijn Gent

  collaborator OTHER

• AZ Sint-Lucas Gent

  collaborator OTHER

• University Hospital, Antwerp

  collaborator OTHER

• AZ Alma

  collaborator OTHER

• AZ Sint-Jan AV

  collaborator OTHER

• University Ghent

  lead OTHER

Principal Investigators

• Jean De Schepper · University Ghent

Study Design

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

6 Years

Max Age

12 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-02-15

Primary Completion

2022-03-31

Completion

2026-12-31

Countries

• Belgium

Study Locations