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Characterization of Persistent Organic Pollutants Exposure During Preconception and Preimplantation Development.

NCT04628091 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2024-07-19

No results posted yet for this study

Summary

In order to evaluate if gametes and preimplantation embryos are in vivo exposed to environmental chemicals, the detection of 6 molecules representative of 3 persistent organic pollutants families will be performed in the mucosa of fallopian tubes obtained after bilateral salpingectomy performed for sterilization purpose in 20 women and compared with concentrations in adipose tissue. This feasibility study is a preliminary step before larger clinical surveys and in vitro studies.

Conditions

  • Exposure to Environmental Pollution

Interventions

OTHER

Sampling on surgery day

In the morning, the day of the surgery (the patient will be fasting): * Occipital hair sample (without roots) * Venous blood sample (3 tubes of 7mL) During the surgery: * Sample of 0.5 to 1 cm3 of subcutaneous adipose tissue during laparoscopic umbilical access * Collection of a portion of Ampulla proximal part and Isthmus distal part in order to obtain a piece of approximately 4 cm long (2cm of ampulla and 2 cm of isthmus) for each tube.

Sponsors & Collaborators

  • University Hospital, Toulouse

    lead OTHER

Principal Investigators

  • Roger LEANDRI, MD · University Hospital, Toulouse

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
43 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-28
Primary Completion
2023-09-18
Completion
2023-09-18

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04628091 on ClinicalTrials.gov