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General Psychological Distress, PTSD, and Co-Morbidities in Healthcare Workers Consequent to COVID-19

NCT04626050 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2025-08-03

No results posted yet for this study

Summary

It is expected that large numbers of healthcare workers will experience a broad range of psychological reactions and symptoms including anxiety, depression, moral distress, and trauma symptoms that will cause both significant suffering as well as occupational and social impairment. The purpose of this study is to find interventions which are helpful in treating psychological distress in healthcare workers caring for COVID-19 patients.

There are two phases of the study. All participants will take part in Phase I, which consists of 4 sessions over a two-week period of either a narrative writing intervention or a medical music intervention. Participants will be randomly assigned to the narrative writing intervention or medical music intervention.

After Phase I, participants will be re-assessed. Healthcare workers who meet criteria for PTSD will be given the option to participate in Phase II of the study, in which they will be offered a choice between one of two evidence-based treatments for PTSD: Interpersonal Therapy (IPT) or Exposure Therapy (ET). Both treatments are comprised of ten 75-minute sessions scheduled twice weekly. Participants will be allowed to choose a preferred treatment in Phase II. After Phase II participants will complete a final assessment concluding the study. All interventions will be offered using distance technology.

Conditions

  • Post-traumatic Stress Disorder
  • Moral Injury

Interventions

BEHAVIORAL

Narrative Writing

Participants randomized to this condition will complete 4 narrative writing sessions over the course of 2 weeks

BEHAVIORAL

Prolonged Exposure Therapy

Psychotherapy including imaginal exposure for PTSD

BEHAVIORAL

Interpersonal Psychotherapy

Psychotherapy that focuses on the effects of PTSD on current interpersonal functioning

BEHAVIORAL

Medical Music

Participants randomized to this condition will complete 4 medical music sessions over the course of 2 weeks

Sponsors & Collaborators

  • Weill Medical College of Cornell University

    lead OTHER

Principal Investigators

  • JoAnn Difede, PhD · Weill Medical College of Cornell University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-01-20
Primary Completion
2028-01-31
Completion
2028-04-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04626050 on ClinicalTrials.gov