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Genomic Profiles Analysis in Children, Adolescents and Young Adult With Sarcomas

NCT04621201 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2023-03-29

No results posted yet for this study

Summary

Bone and soft tissue sarcomas represent about 7-12% of all pediatric cancer and are a heterogeneous group of tumors arising in connective tissues embryologically derived from the mesenchyme. For some of these tumors relapse and mortality rates are still significantly high. Therefore, further studies are needed to better understand pathogenetic processes underlying sarcomas to offer new and more effective treatments. Next generation sequencing (NGS) has opened new frontiers for cancer research allowing to identify somatic or constitutional mutations known or yet unknown with the aim to better understand carcinogenesis. The establishment of the genomic profile of the tumor could also help clinicians to personalize patients treatment based on their genetic and molecular alterations.

Conditions

  • Diagnosed or Relapsed/Refractory Sarcomas

Interventions

OTHER

observation and biopsy

biopsy

Sponsors & Collaborators

  • Associazione Italiana Ematologia Oncologia Pediatrica

    collaborator OTHER

  • Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna

    lead OTHER

Principal Investigators

  • Franca Fagioli, MD · A.O.U. Città della Salute e della Scienza

Eligibility

Max Age
24 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-12-06
Primary Completion
2024-12-06
Completion
2026-12-06

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04621201 on ClinicalTrials.gov