Allogeneic PB103 (NK Cells) Therapy in Non-small Cell Lung Cancer (NSCLC) Patients
NCT04616209 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 24
Last updated 2025-02-14
Summary
Objectives: To determine the safety, tolerability, and efficacy of allogeneic PB103 in patients with IIIb/IV or refractory non-small-cell lung cancer
Conditions
Interventions
- BIOLOGICAL
-
donor-derived NK cell infusion
PB103 administrations will be separated by 4-week interval
Sponsors & Collaborators
-
Tri-Service General Hospital
collaborator OTHER -
Precision Biotech Taiwan Corp.
lead INDUSTRY
Principal Investigators
-
Ming-Shen Dai, MD/PhD · Tri-Service General Hospital
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 20 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-11-15
- Primary Completion
- 2027-12-30
- Completion
- 2027-12-31
Countries
- Taiwan
Study Locations
More Related Trials
-
Optimization of Treatment of Advanced Nonsmall Cell Lung Cancer Using Radiotherapy and Chemotherapy
NCT00864331 ·Status: COMPLETED ·Phase: PHASE3
-
A Trial of SHR-1316/Placebo in Combination With Chemotherapy in Patients With Resectable NSCLC
NCT04316364 ·Status: RECRUITING ·Phase: PHASE3
-
Accelerated Radio-Immunotherapy for Lung Cancer
NCT04577638 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of AL8326 in Non-Small Cell Lung Cancer
NCT06794957 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Safety and Feasibility Study of AGS-003-LNG for the Treatment of Stage 3 Non Small Cell Lung Cancer
NCT02662634 ·Status: WITHDRAWN ·Phase: PHASE2
-
Ivonescimab Monotherapy or in Combination With Chemotherapy as Neoadjuvant/Adjuvant Therapy for Resectable Non-small Cell Lung Cancer
NCT07241819 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Neoadjuvant MPDL3280A, Nab-paclitaxel and Carboplatin (MAC) in NSCLC
NCT02716038 ·Status: COMPLETED ·Phase: PHASE2
-
Proton Beam Radiation Therapy and Chemotherapy in Treating Patients With Stage III Non-Small Cell Lung Cancer That Can Be Removed By Surgery
NCT01076231 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of Effectiveness and Safety of the First-Line Nivolumab Plus Ipilimumab With or Without Chemotherapy for Advanced/Recurrent Non-Small Cell Lung Cancer in Japan
NCT05161325 ·Status: ACTIVE_NOT_RECRUITING
-
A Phase IIII Study of AL8326 in Small Cell Lung Cancer
NCT06247605 ·Status: RECRUITING ·Phase: PHASE3
-
Preconditioning Chemotherapy Combination With Cytokine Induced Killer Cell (CIK) Immunotherapy
NCT01902875 ·Status: UNKNOWN
-
Nogapendekin Alfa Inbakicept for Advanced Non-Small Cell Lung Cancer
NCT03520686 ·Status: TERMINATED ·Phase: PHASE3
-
Neo-Adjuvant Immunotherapy With Nivolumab for Non Small Cell Lung Cancer Patients
NCT03081689 ·Status: COMPLETED ·Phase: PHASE2
-
ICIs Neoadjuvant Therapy in Resectable Non-Small-Cell Lung Cancer
NCT03732664 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of NK012 in Patients With Relapsed Small Cell Lung Cancer
NCT00951613 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase II Randomized Trial of Neoadjuvant Ivonescimab or Penpulimab Plus Chemotherapy in Resectable NSCLC
NCT07086326 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative
NCT04929041 ·Status: SUSPENDED ·Phase: PHASE2/PHASE3
-
A Trial With Metronomic Low-dose Treosulfan, Pioglitazone and Clarithromycin Versus Standard Treatment in NSCLC
NCT02852083 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of NGR-hTNF in Combination With Doxorubicin in Patients Affected by Metastatic Small Cell Lung Carcinoma
NCT00483509 ·Status: COMPLETED ·Phase: PHASE2
-
Randomized, Multi-center, Open-label, Study of PR104 Versus PR104/Docetaxel in Non-Small Cell Lung Cancer (NSCLC)
NCT00862134 ·Status: TERMINATED ·Phase: PHASE2
-
TC-D101 Cell Therapy for Patients With DLL3-Positive SCLC
NCT07246304 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Platinum Doublet Chemotherapy and Proton Beam Radiation Therapy in Treating Patients With Stage II-III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery
NCT03132532 ·Status: COMPLETED ·Phase: PHASE2
-
Randomized Study of Maintenance Therapy With MGN1703 in Patients With SCLC
NCT02200081 ·Status: COMPLETED ·Phase: PHASE2
-
Chemotherapy/Radiotherapy Versus Concomitant Chemotherapy Followed by Radiotherapy in Stage IIIB Non-small Cell Lung Cancer
NCT01652820 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Trial of Regimen for Stage III (N2) NSCLC Using Induction Treatment Followed by Resection
NCT01926483 ·Status: UNKNOWN ·Phase: PHASE2