MedTrace Logo

Vascular Graft Storage Solution Preserves Endothelial Function

NCT04614077 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 12

Last updated 2020-11-03

No results posted yet for this study

Summary

Since Saline is still the most widely used storage and flushing solution in cardiovascular procedures despite knowing evidence of its influence on the human endothelial cell function the main aim of this study was to assess the effect of DuraGraft©, an intraoperative graft treatment solution, on human saphenous vein segments 8 Remnants from the operation after trimming the bypass length), rat aortic segments and human umbilical vein endothelial cells (HUVECs) in comparison to saline.

Conditions

  • Vein Injury

Interventions

OTHER

ex vivo organ bath testing, preservation of vein sections without contact to patient

1 piece of vein is separated during surgical bypass procedure, then randomized and put ex vivo in two solutions: saline and specific solution, then tested in the organ bath

Sponsors & Collaborators

  • Klinikum Floridsdorf

    lead OTHER

Principal Investigators

  • Bernhard Winkler, Associate Professor Priv. Doz. DDR. · Klinikum Floridsdorf

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2020-09-30
Completion
2020-09-30

Countries

  • Austria

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04614077 on ClinicalTrials.gov