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Surfactant Levels in the Lungs of COVID-19 Patients

NCT04609488 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2020-10-30

No results posted yet for this study

Summary

NAME of STUDY: Surfactant levels in the lungs of COVID-19 patients BACKGROUND

* Infection with SARS-CoV-2 may induce respiratory failure.
* COVID-19 associated respiratory failure may require ventilatory support.
* SARS-CoV-2 uses alveolar type II cells for virus replication.
* Alveolar type II cells are responsible for surfactant production and lack of surfactant causes respiratory failure in preterm neonates.
* Lack of surfactant may play role for respiratory failure in COVID-19 patients DESIGN Exploratory prospective study design without therapeutic intervention of any kind. Lung fluid will be donated as part of standard care procedures.

HYPOTHESIS Surfactant is measurable in tracheal secretions by mid-infrared FTIR spectroscopy determined surfactant spectra. Surfactant is reduced in COVID-19 patients requiring ventilator support as compared to non- COVID-19 patients. Dysfunctional surfactant in COVID-19 patients regain its function when respiratory function improves.

POPULATION Main population is patients with COVID-19 pneumonia that requires ventilatory support.

OUTCOME MEASURES Primary outcome is the level of surfactant in lung fluid as obtained by tracheal suction.

SAMPLE SIZE In total 30 patients will be included: twenty COVID-19 patients and 10 non-COVID-19 patients.

Conditions

  • To Assess Surfactant Levels in Lung Fluid

Interventions

DIAGNOSTIC_TEST

Surfactant assessment

To determine surfactant levels in lung fluid

Sponsors & Collaborators

  • Zealand University Hospital

    lead OTHER

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-01
Primary Completion
2022-09-30
Completion
2022-10-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04609488 on ClinicalTrials.gov