Hyper-Personalized Medicine Using Patient Derived Xenografts (PDXovo) for Metastatic Solid Tumors
NCT04602702 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50
Last updated 2022-04-05
Summary
The Investigators will use novel PDX (patient-derived xenograft) technology to form xenografts using material from metastatic solid tumor patients. Xenografts will be treated with a panel of drugs to determine which agent(s) yield the greatest anti-tumor effect on the xenograft.
Conditions
- Kidney Neoplasm
- Carcinoma, Renal Cell
- Metastatic Solid Tumor
Sponsors & Collaborators
-
Sunnybrook Health Sciences Centre
lead OTHER
Principal Investigators
-
Georg Bjarnason, MD · Sunnybrook Hospital/Odette Cancer Centre
-
Elyse Watkins, BSc, PGDip · Sunnybrook Hospital/Odette Cancer Centre
-
Nir Lipsman, MD · Sunnybrook Hospital
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-12-01
- Primary Completion
- 2022-12-31
- Completion
- 2022-12-31
Countries
- Canada
Study Locations
More Related Trials
-
A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)
NCT05722015 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Study of LP002 in Combination With Chemotherapy for Patients With Extensive Stage Small Cell Lung Cancer
NCT04740021 ·Status: UNKNOWN ·Phase: PHASE2
-
Pembrolizumab Plus Bevacizumab and Chemotherapy for Non-Squamous NSCLC Patients
NCT05751187 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Patient-derived Xenograft (PDX) Modeling to Test Drug Response for High-grade Osteosarcoma
NCT03358628 ·Status: UNKNOWN
-
A Phase 2 Trial of AMG 706 or Bevacizumab in Combination With Chemo for Advanced NSCLC
NCT00369070 ·Status: TERMINATED ·Phase: PHASE2
-
10-Propargyl-10-Deazaaminopterin in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
NCT00004238 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Study of Chemotherapy and PD-1 Inhibitor Combination With Autologous CIK Cell Immunotherapy to Treat Lung Cancer
NCT04836728 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of RGX-104 in Patients With Advanced Lung & Endometrial Cancer
NCT02922764 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of IMU-201 (PD1-Vaxx), a B-Cell Immunotherapy, in Adults With Non-Small Cell Lung Cancer
NCT04432207 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase II Study to Evaluate the Efficacy and Safety of HLX43 + Serplulimab as Neoadjuvant Therapy in Subjects With NSCLC
NCT07269782 ·Status: RECRUITING ·Phase: PHASE2
-
A Phase II Clinical Study to Evaluate HLX43 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC)
NCT06907615 ·Status: RECRUITING ·Phase: PHASE2
-
SX-682 With Pembrolizumab for the Treatment of Metastatic or Recurrent Stage IIIC or IV Non-Small Cell Lung Cancer
NCT05570825 ·Status: RECRUITING ·Phase: PHASE2
-
Study of Pemetrexed+Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Participants With First Line Metastatic Nonsquamous Non-small Cell Lung Cancer (MK-3475-189/KEYNOTE-189)
NCT02578680 ·Status: COMPLETED ·Phase: PHASE3
-
Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors
NCT03836352 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Datopotamab Deruxtecan (Dato-DXd) for Non-Small Cell Lung Cancer (NSCLC) Patients With Active Brain Metastases
NCT06676917 ·Status: WITHDRAWN ·Phase: PHASE2
-
Inhaled Doxorubicin in Treating Patients With Primary Lung Cancer or Lung Metastases
NCT00004930 ·Status: COMPLETED ·Phase: PHASE1
-
A Safety Study of Oral Venetoclax in Combination With Intravenous Pembrolizumab in Adult Participants With Previously Untreated Non-Small Cell Lung Cancer (NSCLC) With High Programmed Cell Death Ligand-1 (PD-L1) Expression
NCT04274907 ·Status: TERMINATED ·Phase: PHASE1
-
Study of Nivolumab-Ipilimumab and cfDNA in Lung Cancer
NCT04966676 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of HLX10 in Combination With Carboplatin Plus (+) Pemetrexed With or Without HLX04 Compared With Carboplatin+Pemetrexed in 1L Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
NCT03952403 ·Status: UNKNOWN ·Phase: PHASE3
-
Bevacizumab, Docetaxel, and Gemcitabine Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer
NCT00970684 ·Status: COMPLETED ·Phase: PHASE2
-
Neoadjuvant Pemetrexed, Carboplatin and Bevacizumab in Unresectable, Locally Advanced Lung Adenocarcinoma
NCT01588704 ·Status: COMPLETED ·Phase: PHASE2
-
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
NCT06758401 ·Status: RECRUITING ·Phase: PHASE3
-
HX008 Plus Chemotherapy VS Pembrolizumab Plus Chemotherapy As the First-line Treatment in Participants With Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer
NCT04750083 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
Patient-derived Organoid Drug Sensitivity Guided Treatment for Drug-resistant Recurrent Non-Small Cell Lung Cancer
NCT06406608 ·Status: RECRUITING ·Phase: NA
-
Long-term Outcomes Among Patients With Programmed Death-ligand 1 <1% Metastatic Non-small Cell Lung Cancer Treated With First-line Nivolumab + Ipilimumab + 2 Cycles of Chemotherapy
NCT07024862 ·Status: ACTIVE_NOT_RECRUITING