COVID-19: Pediatric Research Immune Network on SARS-CoV-2 and MIS-C

Summary

The primary objectives of this study are:

* To determine the proportion of children with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) related death, rehospitalization or major complications after infection with SARS-CoV-2 and/or Multisystem Inflammatory Syndrome in Children (MIS-C), and
* To determine immunologic mechanisms and immune signatures associated with disease spectrum and subsequent clinical course during the year of follow-up.

Conditions

• Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
• Multisystem Inflammatory Syndrome in Children (MIS-C)
• Coronavirus Disease 2019 (COVID-19)

Interventions

OTHER

SARS-CoV-2 and/or MIS-C Exposure

This is an observational cohort study.

Sponsors & Collaborators

• Autoimmunity Centers of Excellence

  collaborator OTHER

• Clinical Trials in Organ Transplantation in Children

  collaborator OTHER

• National Institute of Allergy and Infectious Diseases (NIAID)

  lead NIH

Principal Investigators

• Steven A. Webber, MBChB, MRCP · Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt

• James D. Wilkinson, MD, MPH · Vanderbilt Institute for Clinical and Translational Research (VICTR)

• Natasha B Halasa, MD, MPH · Department of Pediatrics, Vanderbilt University Medical Center

• Virginia Pascual, MD · Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine

• Betty Diamond, MD · Institute of Molecular Medicine, The Feinstein Institute for Medical Research

• Ignacio Sanz, MD · Division of Rheumatology, Emory University

• Olivia Martinez, PhD · Stanford University

• Sheri Krams, PhD · Stanford University

• Jeremy Boss, PhD · Emory University

Eligibility

Max Age

20 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-11-19

Primary Completion

2023-03-03

Completion

2023-03-03

Countries

• United States

Study Locations