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Randomized, Double-Blind Evaluation of Maple Leaf Extract (Maplifa) for Photoaging

NCT04586816 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2020-10-14

No results posted yet for this study

Summary

Recent research has reported that the maple leaf extract exhibits anti-aging effects by inhibiting elastase activity, thereby preventing the breakdown of elastin and interfering with the formation of wrinkles. Red maple leaf extract contains phenolic compounds known as glucitol-core-containing gallotannins (GCGs) which help reduce the appearance of wrinkles and may decrease skin inflammation, dark spots and pigmentation. The objective of this study is to examine the effects of topical Maplifa on the cosmetic appearance of facial lines, redness and skin tone.

Conditions

  • Photoaging
  • Hyperpigmentation
  • Rhytides

Interventions

COMBINATION_PRODUCT

1% red maple leaf extract in cream base

1% red maple leaf extract is combined in a cream base

COMBINATION_PRODUCT

5% red maple leaf extract

5% red maple leaf extract is combined in a cream base

COMBINATION_PRODUCT

vehicle

vehicle cream base only

Sponsors & Collaborators

  • Verdure Sciences

    collaborator INDUSTRY

  • Integrative Skin Science and Research

    lead INDUSTRY

Principal Investigators

  • Raja K Sivamani, MD · Integrative Skin Science and Research

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
70 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-09-10
Primary Completion
2020-01-15
Completion
2020-01-15

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04586816 on ClinicalTrials.gov