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Transcranial Magnetic Stimulation to Augment Behavior Therapy for Tics

NCT04578912 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2025-03-07

Study results available
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Summary

The study will examine whether combining Comprehensive Behavioral Intervention for Tics (CBIT) with inhibition of the supplementary motor area (SMA) using transcranial magnetic stimulation (TMS) normalizes activity in the SMA-connected circuits, improves tic suppression ability, and enhances CBIT outcomes in young people with tic disorder. The study will also examine different TMS dosing strategies.

Conditions

  • Tic Disorders
  • Tics
  • Tic, Motor
  • Tic Disorder, Childhood
  • Tourette Syndrome
  • Tourette Syndrome in Children
  • Tourette Syndrome in Adolescence

Interventions

BEHAVIORAL

Comprehensive Behavioral Intervention for Tics (CBIT)

CBIT is a manualized treatment program focused on tic management skills

DEVICE

Repetitive Transcranial Magnetic Stimulation (rTMS)

During repetitive transcranial magnetic stimulation (rTMS), a electromagnetic coil is placed against the scalp while an electromagnet painlessly delivers a magnetic pulse that stimulates nerve cells in the target brain region

DEVICE

Continuous Theta Burst Stimulation (cTBS)

During continuous theta burst stimulation (cTBS), a electromagnetic coil is placed against the while an electromagnet painlessly delivers magnetic bursts that stimulate nerve cells in the target brain region

Sponsors & Collaborators

Principal Investigators

  • Christine Conelea, PhD · University of Minnesota

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
12 Years
Max Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-01
Primary Completion
2023-12-31
Completion
2023-12-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04578912 on ClinicalTrials.gov