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Obesity in Sleep Medicine - Focusing on OHS Phenotypes

NCT04570540 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 82

Last updated 2020-09-30

No results posted yet for this study

Summary

This study focuses on a comprehensive examination of obese patients with sleep-related breathing disorders including patients with OSA, sleep hypoventilation and OHS. The aim of this study is to (1) evaluate characteristics of and differences between severity levels of obesity-related breathing disorders, (2) discuss pathophysiological variables associated with hypoventilation during sleep or at daytime and (3) find functional parameters indicating sleep hypoventilation.

Conditions

  • Obesity Hypoventilation Syndrome (OHS)

Interventions

DIAGNOSTIC_TEST

Sleep Study

Full-night attended in-lab polysomnography with accompanying transcutaneous capnometry

DIAGNOSTIC_TEST

Pulmonary Function Test

Bodyplethysmographic assessment

DIAGNOSTIC_TEST

Hypercapnic ventilatory response

Measurement of hypercapnic ventilatory response based on the method described by Read in 1967, using a rebreathing bag

DIAGNOSTIC_TEST

Cardiopulmonary Exercise Test

Symptom-limited cardiopulmonary exercise test with a ramp protocol according to the ATS/ACCP and ERS recommendations

Sponsors & Collaborators

  • Philips Respironics

    collaborator INDUSTRY

  • Wissenschaftliches Institut Bethanien e.V

    lead OTHER

Principal Investigators

  • Winfried J Randerath, Prof. Dr. · Chief Physician

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-04-24
Primary Completion
2019-09-10
Completion
2019-09-10

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04570540 on ClinicalTrials.gov