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Preschool Bronchial Remodeling and Risk of Exacerbation

NCT04558671 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 56

Last updated 2020-09-29

No results posted yet for this study

Summary

Bronchial remodeling is an abnormal tissue repair process of the bronchial wall components that characterizes severe asthma which can include epithelial abrasion, thickening of the reticular basement membrane (RBM), an increase in bronchial fibrosis, blood vessel count, mucosal gland mass and/or bronchial smooth muscle (BSM) mass. We identified using latent class analysis two classes of patients. Compared to the second class, the first class was characterized by an increase in RBM thickness, blood vessel count, BSM mass and a decrease in RBM-BSM distance, mucus gland mass and bronchial fibrosis. We then hypothesized that this first latent class identified children at risk of asthma exacerbations.

Conditions

  • Preschool Severe Asthma

Interventions

OTHER

asthma exacerbations

to collect the number of asthma exacerbations between the 2 latent classes of patients within the year following bronchoscopy

Sponsors & Collaborators

  • University Hospital, Bordeaux

    lead OTHER

Eligibility

Min Age
1 Year
Max Age
5 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-16
Primary Completion
2020-09-24
Completion
2020-09-24

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04558671 on ClinicalTrials.gov