Camrelizumab Combined With Apatinib in Patients With PD-1 Antagonists Resistant Recurrent/Metastatic Nasopharyngeal Carcinoma
NCT04548271 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 25
Last updated 2020-09-14
Summary
The purpose of this study is to explore the efficacy and safety of combination of Apatinib and Camrelizumab regimen in treating recurrent or metastatic nasopharyngeal carcinoma patients who were resistant to PD-1 antagonists.
Conditions
- Nasopharyngeal Carcinoma
Interventions
- DRUG
-
Camrelizumab
Anti-PD-1 targeted immunotherapy
- DRUG
-
Apatinib
A small-molecule vascular endothelial growth factors receptor (VEGFR) tyrosine kinase inhibitor
Sponsors & Collaborators
-
Sun Yat-sen University
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-09-30
- Primary Completion
- 2022-10-31
- Completion
- 2023-10-31
Countries
- China
Study Locations
More Related Trials
-
Phase Ⅱ Trial of Camrelizumab in Patients Without Distant Metastasis Nasopharyngeal Carcinoma
NCT04782765 ·Status: UNKNOWN ·Phase: PHASE2
-
Apatinib Combined With PD-1 in the Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma
NCT04350190 ·Status: COMPLETED ·Phase: PHASE2
-
Camrelizumab Plus Stereotactic Body Radiotherapy vs Camrelizumab Alone For Oligometastatic Nasopharyngeal Carcinoma
NCT04944914 ·Status: RECRUITING ·Phase: PHASE3
-
Efficacy and Safety of TPC+Apatinib+Camrelizumab vs GP+ Camrelizumab for High-Risk Nasopharyngeal Carcinoma: A Phase 3 Trial
NCT06438627 ·Status: RECRUITING ·Phase: PHASE3
-
Camrelizumab Combined With Apatinib in the Treatment of Advanced Sarcomatoid Carcinoma or Carcinosarcoma
NCT05265793 ·Status: UNKNOWN ·Phase: PHASE2
-
SBRT Combined With PD-1 Antibody and Chemotherapy in Oligometastatic Nasopharyngeal Carcinoma
NCT05524168 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Camrelizumab Plus Chemoradiotherapy for Patients With Locoregional Cancer of Nasal Cavity and Paranasal Sinuses
NCT05114707 ·Status: UNKNOWN ·Phase: PHASE2
-
Fluzoparib and Camrelizumab in Treating Patients With R/M NPC That Progressed After First-line Chemotherapy
NCT04978012 ·Status: RECRUITING ·Phase: PHASE2
-
Induction Chemotherapy Combined With Camrelizumab in Locoregionally Advanced Hypopharyngeal Cancer
NCT04539600 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study of Camrelizumab Plus Apatinib as Consolidation Therapy in Non-Small Cell Lung Cancer Patients Treated With Chemoradiotherapy
NCT04749394 ·Status: UNKNOWN ·Phase: PHASE2
-
Programmed Death-1 (PD-1) Antibody Combined With Chemoradiotherapy in High-risk Recurrent Nasopharyngeal Carcinoma
NCT03930498 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Two Cycles Versus Three Cyclle of CCRT for Low Risk Locoregionally Advanced Nasopharyngeal Carcinoma
NCT02871518 ·Status: UNKNOWN ·Phase: PHASE2
-
Comparing Chemotherapy With/Without Toripalimab For Primary Metastatic Nasopharyngeal Carcinoma
NCT04517214 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Camrelizumab After Completion of Radiotherapy for Oligometastatic Nasopharyngeal Carcinoma
NCT04221516 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study to Evaluate Camrelizumab in Combination With Nb-Paclitaxel in Patients With Advanced or Metastatic NSCLC
NCT04167774 ·Status: UNKNOWN ·Phase: PHASE2
-
Reduced-dose Radiotherapy for Low-risk Stage III Patients With Nasopharyngeal Carcinoma
NCT03668730 ·Status: UNKNOWN ·Phase: PHASE2
-
Concurrent and Adjuvant PD1 Treatment Combined With Chemo-radiotherapy for High-risk Nasopharyngeal Carcinoma
NCT04453826 ·Status: RECRUITING ·Phase: PHASE3
-
SHR-1701 in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma
NCT04282070 ·Status: UNKNOWN ·Phase: PHASE1
-
Anti-PD1 Monoclonal Antibody Combined With Nimotuzumab and Capecitabine in Patients With First-line Platinum-resistant Recurrent/Metastatic Nasopharyngeal Carcinoma
NCT06259721 ·Status: RECRUITING ·Phase: PHASE2
-
Camrelizumab for the Treatment of Locally Advanced Nasopharyngeal Carcinoma
NCT05097209 ·Status: RECRUITING ·Phase: PHASE2
-
Camrelizumab Combined With SRT/WBRT and Chemotherapy in Patients With Brain Metastases of Driven Gene-negative NSCLC
NCT04768075 ·Status: COMPLETED ·Phase: PHASE3
-
GP Plus Adebrelimab Versus GP Neoadjuvant Chemotherapy for Nasopharyngeal Carcinoma
NCT06455410 ·Status: RECRUITING ·Phase: PHASE2
-
Chemotherapy Plus Subsequent Loco-regional Radiotherapy Combined With Toripalimab in the De Novo Metastatic Nasopharyngeal Carcinoma
NCT04398056 ·Status: UNKNOWN ·Phase: PHASE2
-
Whole-target Consolidation Therapy Under Systemic Therapy for Oligometastatic Nasopharyngeal Carcinoma
NCT05431764 ·Status: RECRUITING ·Phase: PHASE2
-
PD-1 Blockade Combined With De-intensified Chemoradiotherapy Sparing Concurrent Cisplatin in Nasopharyngeal Carcinoma
NCT04907370 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3