Camrelizumab Combined With Apatinib in Patients With First-line Platinum-resistant Recurrent/Metastatic Nasopharyngeal Carcinoma
NCT04547088 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 27
Last updated 2020-09-14
Summary
The purpose of this study is to explore the efficacy and safety of a combination of Camrelizumab and Apatinib regimen in treating recurrent or metastatic nasopharyngeal carcinoma patients who have failed first-line platinum-based chemotherapy.
Conditions
- Nasopharyngeal Carcinoma
Interventions
- DRUG
-
Camrelizumab
Anti-PD-1 targeted immunotherapy
- DRUG
-
Apatinib
A small-molecule vascular endothelial growth factors receptor (VEGFR) tyrosine kinase inhibitor
Sponsors & Collaborators
-
Sun Yat-sen University
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-09-30
- Primary Completion
- 2022-10-31
- Completion
- 2023-10-31
Countries
- China
Study Locations
More Related Trials
-
Camrelizumab Combined With Pemetrexed and Carboplatin for the Study of EGFR-mutated Lung Squamous NSCLC Treatment
NCT04970043 ·Status: UNKNOWN ·Phase: NA
-
Apatinib as Second Line Therapy in Patients With Advanced Refractory Biliary Tract Cancers
NCT03144856 ·Status: UNKNOWN ·Phase: PHASE2
-
Chemotherapy Combined With Camrelizumab and Apatinib in First-line Treatment of ES-SCLC
NCT05001412 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study of Apatinib in Patients With Advanced Non-squamous and Non-small Cell Lung Cancer
NCT01270386 ·Status: COMPLETED ·Phase: PHASE2
-
Multicenter, Prospective, Real World Study of Camrelizumab in Cross-line Treatment of Non-small Cell Lung Cancer
NCT05547737 ·Status: UNKNOWN
-
Anlotinib in Recurrent or Metastatic Nasopharyngeal Carcinoma Patients After Failure of no Less Than Second-line Therapy
NCT03906058 ·Status: COMPLETED ·Phase: PHASE2
-
Surufatinib Combined With Toripalimab and Chemotherapy in the Treatment of Non-Small Cell Lung Cancer
NCT05003037 ·Status: UNKNOWN ·Phase: PHASE2
-
Maintenance Therapy of Apatinib After Chemoradiotherapy in Metastatic Nasopharyngeal Carcinoma
NCT03180476 ·Status: COMPLETED ·Phase: PHASE2
-
Erlotinib Intercalated With Chemotherapy Versus Erlotinib as First Line Treatment in Stage IIIB/IV NSCLC Patients With EGFR Mutation
NCT02001896 ·Status: UNKNOWN ·Phase: PHASE3
-
The Efficacy and Safety of Apatinib in Heavily Pretreated Advanced Non-squamous Non-small Cell Lung Cancer
NCT02515435 ·Status: UNKNOWN ·Phase: PHASE2
-
Clinical Study of Ametinib Combined With Bevacizumab in First-line Treatment of Advanced NSCLC With EGFR-mutations.
NCT05754736 ·Status: RECRUITING ·Phase: PHASE2
-
Anti-PD-1 Antibody Therapies of Camrelizumab in Combination With Pemetrexed and Carboplatin as First-line Treatment in Patients With Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
NCT05841472 ·Status: RECRUITING ·Phase: PHASE2
-
Efficacy and Safety of Sintilimab With or Without Radiotherapy in Patients With Recurrent or IV NSCLC (EGFR -, ALK -) After Failure of Platinum-based Chemotherapy: A Randomized,Open Labled, Phase II Clinical Study
NCT04513301 ·Status: UNKNOWN ·Phase: PHASE2
-
An Exploratory Clinical Study of Adebelimumab in Combination With Famitinib and Chemotherapy in Patients With NSCLC
NCT06332300 ·Status: WITHDRAWN ·Phase: PHASE2
-
The Efficacy and Drug Resistance Molecular Biology of Apatinib Combined With EGFR-TK1 Treated for Advanced Slow-progressed Non-Small Cell Lung Cancer (NSCLC)
NCT03811054 ·Status: UNKNOWN ·Phase: PHASE2
-
the Efficacy and Safety of Anlotinib Combined With Almonertinib in the First-line Treatment of Patients With Brain Metastases From EGFR Mutation-positive Non-small Cell Lung Cancer
NCT04978753 ·Status: UNKNOWN ·Phase: PHASE2
-
A Phase III Study to Assess the Efficacy and Safety of Almonertinib Versus Platinum-based Chemotherapy as First-line Therapy in Patients With Locally Advanced or Metastatic NSCLC Harbouring Uncommon EGFR Mutation
NCT04951648 ·Status: UNKNOWN ·Phase: PHASE3
-
Phase Ib/II Study of Vebreltinib With Furmonertinib in NSCLC Patients With c-Met Amplification After EGFR-TKI Failure
NCT07087223 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of Almonertinib Combined With Palbociclib in Patients With Advanced Solid Tumors Harboring KRAS Mutations
NCT06947811 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Apatinib Combine With Platinum-Based Doublet Chemotherapy for First-line Treatment of Advanced NSCLC
NCT03201146 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Study of Gefitinib With or Without Apatinib in Patients With Advanced Non-squamous Non-Small-Cell Lung Cancer Harboring EGFR Mutations
NCT02824458 ·Status: UNKNOWN ·Phase: PHASE3
-
Study of Apatinib as 3rd/4th Line Treatment in Patients With Advanced Non-Squamous Non-small Cell Lung Cancer Harboring Wild-type Epidermal Growth Factor Receptor (EGFR)
NCT02332512 ·Status: UNKNOWN ·Phase: PHASE3
-
Apatinib Combined With Chemotherapy for NSCLC Patients Without T790M Mutation
NCT03758677 ·Status: UNKNOWN ·Phase: PHASE2
-
Apatinib in the Treatment of Advanced Non-squamous Non-small Cell Lung Cancer
NCT01287962 ·Status: UNKNOWN ·Phase: PHASE3
-
Neoadjuvant Osimertinib + Chemotherapy for EGFR-mutant Stage III NSCLC
NCT05011487 ·Status: RECRUITING ·Phase: PHASE2