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General Anesthesia and Paravertebral Blocks vs. General Anesthesia Only: Influence Inflammation Factors and Clinical Outcomes in Modified Radical Mastectomy

NCT04540055 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 88

Last updated 2021-01-22

No results posted yet for this study

Summary

Regional anesthesia and analgesia may maintain immune function, reduce surgical stress, and also reduce volatile anesthetics and opioids requirements. Local anesthetic drugs used in regional anesthesia and analgesia work to have anti-proliferative and cytotoxic effects on cancer cells. Pro-inflammatory cytokines such as IL-1, IL-6, and TNF-alpha increase in levels in peripheral nerves, spinal cord, brain (brain stem, locus sereleus, thalamus, hippocampus, and prefrontal cortex) after peripheral nerves are injured. The anti-inflammatory cytokine IL-10 is decreased in levels after peripheral nerve injury. The balance between pro-inflammatory and anti-inflammatory cytokines affects the severity of pain.

Conditions

  • Anesthesia, Local
  • Anesthesia
  • Inflammatory Response
  • Pain, Postoperative

Interventions

PROCEDURE

Paravertebral block

The subjects in this group received general anesthesia and USG-guided paravertebral block

PROCEDURE

General Anesthesia

The subjects in this group underwent MRM under routine general anesthesia without peripheral nerve block supplementation.

Sponsors & Collaborators

  • Udayana University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-10-01
Primary Completion
2020-12-30
Completion
2021-01-21

Countries

  • Indonesia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04540055 on ClinicalTrials.gov