Pegylated Interferon Lambda for Treatment of COVID-19 Infection
NCT04534673 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 9
Last updated 2026-04-30
Summary
A randomized, open-label, 2 arm, pilot trial of Lambda 180 mcg administered subcutaneously once weekly, for up to two weeks (2 injections at most), in addition to standard supportive care, compared to standard supportive care alone, in a population of COVID-19 infected patients.
patients will be randomized according to 1:1 ratio to one of the 2 trial arms: Lambda 180 mcg S.C + standard care (intervention arm) or standard care only (control arm).
Conditions
Interventions
- DRUG
-
Lambda 180 mcg S.C
Prefilled injection syringe of 180 microgram Pegylated interferon lambda, administered on day 0 and if needed on day 7
Sponsors & Collaborators
-
Soroka University Medical Center
lead OTHER
Principal Investigators
-
Ohad Etzion, MD · Soroka Univeersity Medical Center
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-04-07
- Primary Completion
- 2023-02-16
- Completion
- 2023-02-16
Countries
- Israel
Study Locations
More Related Trials
-
Interferon Lambda Therapy for COVID-19
NCT04388709 ·Status: WITHDRAWN ·Phase: PHASE2
-
Pegylated Interferon - α2b With SARSCoV- 2 (COVID-19)
NCT04480138 ·Status: TERMINATED ·Phase: PHASE2
-
CPI-006 Plus Standard of Care Versus Placebo Plus Standard of Care in Mild to Moderately Symptomatic Hospitalized Covid-19 Patients
NCT04734873 ·Status: TERMINATED ·Phase: PHASE3
-
Study to Assess Efficacy and Safety of Inhaled Interferon-β Therapy for COVID-19
NCT04732949 ·Status: COMPLETED ·Phase: PHASE3
-
Safety, Tolerability and Efficacy of S-1226 in Post-COVID-19 Subjects With Persistent Respiratory Symptoms.
NCT04949386 ·Status: UNKNOWN ·Phase: PHASE2
-
Pilot Clinical Trial to Explore Efficacy and Safety of Pyramax in Mild to Moderate COVID-19 Patients
NCT05633420 ·Status: COMPLETED ·Phase: PHASE2
-
Piclidenoson for Treatment of COVID-19
NCT04333472 ·Status: COMPLETED ·Phase: PHASE2
-
Safety, PK and PD of Kamada Anti-SARS-CoV-2 in COVID-19
NCT04550325 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study to Evaluate the Efficacy and Safety of Leronlimab for Mild to Moderate COVID-19
NCT04343651 ·Status: COMPLETED ·Phase: PHASE2
-
A Study on the Effects in Healthy People of a New Drug Called PDI204 for Treating COVID-19
NCT06965751 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Study to Evaluate STI-1499 (COVI-GUARD) in Patients With Moderate COVID-19
NCT04454398 ·Status: WITHDRAWN ·Phase: PHASE1
-
Study in Participants With Early Stage Coronavirus Disease 2019 (COVID-19) to Evaluate the Safety, Efficacy, and Pharmacokinetics of Remdesivir Administered by Inhalation
NCT04539262 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study to Evaluate the Efficacy and Safety of IV Peramivir in Addition to Standard of Care Compared to Standard of Care Alone in Adults and Adolescents Who Are Hospitalized Due to Influenza
NCT00958776 ·Status: TERMINATED ·Phase: PHASE3
-
A Study to Learn About the Study Medicines (Nirmatrelvir Plus Ritonavir) in People Aged 12 Years or Older With COVID-19 and a Compromised Immune System
NCT05438602 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluation of the Effectiveness of Therapy for Patients With Covid-19 Using Food Supplements Viusid + Asbrip
NCT04980534 ·Status: COMPLETED ·Phase: NA
-
First-In-Human Study To Evaluate Safety, Tolerability, And Pharmacokinetics Following Single Ascending And Multiple Ascending Doses of PF-07304814 In Hospitalized Participants With COVID-19.
NCT04535167 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Immunogenicity Study of an Inactivated SARS-CoV-2 Vaccine for Preventing Against COVID-19 in People Aged ⩾60 Years
NCT04470609 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of a Potential Oral Treatment to Prevent COVID-19 in Adults Who Are Exposed to Household Member(s) With a Confirmed Symptomatic COVID-19 Infection
NCT05047601 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Efficacy and Safety of Molnupiravir (MK-4482) in Hospitalized Adult Participants With COVID-19 (MK-4482-001)
NCT04575584 ·Status: TERMINATED ·Phase: PHASE2/PHASE3
-
A Phase II, Multicenter, Randomized, Placebo -Controlled, Study To Evaluate The Efficacy and Safety Of Intramuscular Peramivir 600 mg In Subjects With Uncomplicated Acute Influenza
NCT00705406 ·Status: COMPLETED ·Phase: PHASE2
-
Ivermectin vs. Placebo for the Treatment of Patients With Mild to Moderate COVID-19
NCT04429711 ·Status: UNKNOWN ·Phase: NA
-
Clinical Study for the Treatment With Interferon-ß-1a (IFNß-1a) of COVID-19 Patients
NCT04449380 ·Status: TERMINATED ·Phase: PHASE2
-
Levamisole and Isoprinosine in Immune-prophylaxis of Egyptian Healthcare Workers Facing COVID-19
NCT04360122 ·Status: UNKNOWN ·Phase: PHASE3
-
PF-07304814 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)
NCT05780541 ·Status: TERMINATED ·Phase: PHASE3
-
Efficacy and Safety of Liposomal Lactoferrin in COVID-19 Patients With Mild-to-Moderate Disease and in COVID-19 Asymptomatic Patients
NCT04475120 ·Status: COMPLETED ·Phase: PHASE2/PHASE3