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Colorectal Adenoma Canceration in FAP

NCT04531930 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 124

Last updated 2020-08-31

No results posted yet for this study

Summary

The current internationally accepted treatment method for familial adenomatous polyposis is prophylactic total colorectal resection combined with endoscopic follow-up. However, total colorectal resection will bring a sharp decline in the quality of life of patients. Therefore, how to improve treatment methods and improve the quality of life for such patients under the premise of medical quality is the current medical focus. This study intends to establish three parallel observation cohorts, namely the surgical treatment group, the intensive colonoscopy treatment group, and the autonomous monitoring group. During the three-year study period, the investigators observed changes in the number of adenomas, carcinogenesis, and medical expenses in each group during the 3-year study period, and compared the groups to determine whether the intensive colonoscopy therapy has the possibility of delaying or replacing preventive surgery.

Conditions

Interventions

PROCEDURE

surgery

Colorectal surgery, mainly total proctocolectomy.

PROCEDURE

enhanced colonoscopy

Colonoscopic treatment and surveillance in every 3 months.

OTHER

self choosed methods

A patient chooses a method for himself other than surgery.

Sponsors & Collaborators

  • Changhai Hospital

    lead OTHER

Principal Investigators

  • Jun-Jie XING, MD · Changhai Hospital

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-10-01
Primary Completion
2023-09-30
Completion
2030-09-30

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04531930 on ClinicalTrials.gov