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Differences in Immune Response Among HIV-1-infected Individuals With Previous or Current COVID-19 (CoVIHDis).

NCT04526977 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2022-10-18

No results posted yet for this study

Summary

People living with HIV could have different susceptibility and outcome to the SARS CoV-2 infection. The risk of SARS CoV-2 infection in this population could be no related to HIV infection, immunodepression or antiretroviral therapy, but to the different susceptibility as measured by ACE2 or CD26 receptors. Also, patients with HIV-1 infection could have different cytokine profile and cellular immune response after SARS-CoV-2 infection, leading to a differential outcome,

Conditions

Interventions

DIAGNOSTIC_TEST

Immune response study

* ACE2 and CD26 receptor study * Cytokine profile: Quantification of plasma cytokine levels * SARS-CoV-2 CD4/CD8 T cell response * TLR7/8 activation * KIR characterization

Sponsors & Collaborators

  • Asociacion para el Estudio de las Enfermedades Infecciosas

    lead NETWORK

Principal Investigators

  • Jose L Casado, PhD · Hospital Ramon y Cajal

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-10
Primary Completion
2022-12-30
Completion
2023-03-30

Countries

  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04526977 on ClinicalTrials.gov