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SMAD2, SMAD3 AND TGF-β GENE EXPRESSION IN URGE URINARY INCONTINENCE

NCT04525105 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 24

Last updated 2020-08-25

No results posted yet for this study

Summary

Urge urinary incontinence (UUI) is a common health problem. Changes in collagen metabolism in pelvic support organs, such as uterosacral ligaments (USLs), might be responsible for the complex pathophysiology of UUI. The TGF-β pathway is involved in collagen synthesis and degradation. The Transforming Growth Family- β (TGF-β) superfamily has essential intracellular signaling components, such as newly identified SMAD family members. We evaluated the changes in the levels of TGF-β and SMAD gene and protein expression in the USL of patients with concomitant pelvic organ prolapse (POP) and UUI.

Conditions

  • SMAD2
  • SMAD3
  • TGF-β
  • Pelvic Organ Prolapse
  • Urge Urinary Incontinence

Interventions

GENETIC

SMAD2

a family of structurally related cytokines

Sponsors & Collaborators

  • Muğla Sıtkı Koçman University

    lead OTHER

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-11-01
Primary Completion
2020-01-01
Completion
2020-01-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04525105 on ClinicalTrials.gov