Short-Course Chemoradiotherapy Followed by Chemotherapy for the Treatment of Resectable Gastric Adenocarcinoma
NCT04523818 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 25
Last updated 2026-01-14
Summary
This phase Ib trial investigates the side effects and how well a shorter course of chemotherapy and radiation treatment (chemoradiotherapy) for 2 weeks instead of 5 weeks followed by standard chemotherapy works in treating patients with gastric cancer who are scheduled to have treatment and then surgery to remove the tumor. Chemotherapy drugs, such as capecitabine and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy sources to kill tumor cells and shrink tumors. Giving short-course chemo-radiotherapy before chemotherapy and surgery may help to control the disease.
Conditions
- Clinical Stage I Gastric Cancer AJCC v8
- Clinical Stage IIA Gastric Cancer AJCC v8
- Clinical Stage III Gastric Cancer AJCC v8
- Clinical Stage IVA Gastric Cancer AJCC v8
- Gastric Adenocarcinoma
- Pathologic Stage IB Gastric Cancer AJCC v8
- Pathologic Stage II Gastric Cancer AJCC v8
- Pathologic Stage IIA Gastric Cancer AJCC v8
- Pathologic Stage IIB Gastric Cancer AJCC v8
- Pathologic Stage III Gastric Cancer AJCC v8
- Pathologic Stage IIIA Gastric Cancer AJCC v8
- Pathologic Stage IIIB Gastric Cancer AJCC v8
- Pathologic Stage IIIC Gastric Cancer AJCC v8
- Postneoadjuvant Therapy Stage I Gastric Cancer AJCC v8
- Postneoadjuvant Therapy Stage II Gastric Cancer AJCC v8
- Postneoadjuvant Therapy Stage III Gastric Cancer AJCC v8
Interventions
- DRUG
-
Given PO
- DRUG
-
Given IV
- RADIATION
-
Radiation Therapy
Undergo radiation therapy
- PROCEDURE
-
Therapeutic Surgical Procedure
Undergo standard of care surgery
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
M.D. Anderson Cancer Center
lead OTHER
Principal Investigators
-
Brian D Badgwell · M.D. Anderson Cancer Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-08-11
- Primary Completion
- 2028-12-31
- Completion
- 2028-12-31
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Neoadjuvant Chemoradiotherapy vs. Chemotherapy Followed by Radical Gastrectomy and Adjuvant Chemotherapy for Advanced Gastric Cancer
NCT01815853 ·Status: COMPLETED ·Phase: PHASE3
-
A Randomized Phase II Trial of Neoadjuvant Chemotherapy Compared With Chemoradiotherapy in Gastric Adenocarcinoma
NCT02301481 ·Status: COMPLETED ·Phase: PHASE2
-
Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer
NCT00052910 ·Status: COMPLETED ·Phase: PHASE3
-
Preoperative Chemo and Chemoradiotherapy for Adenocarcinoma of the Stomach and Gastroesophageal Junction (GEJ)
NCT00525785 ·Status: COMPLETED ·Phase: PHASE2
-
Perioperative Chemoradiotherapy for Potentially Resectable Gastric Cancer
NCT00420394 ·Status: UNKNOWN ·Phase: PHASE2
-
Trial of Adjuvant Chemotherapy for Gastric Cancer
NCT00296335 ·Status: COMPLETED ·Phase: PHASE3
-
Postoperative Chemoradiotherapy With S-1 in Gastric Cancer
NCT01824004 ·Status: COMPLETED ·Phase: PHASE2
-
Mecapegfilgrastim Combined With Adebrelimab and Chemotherapy as Neoadjuvant Therapy in Resectable GC/GEJC
NCT06684158 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Trial of Preoperative Therapy for Gastric and Esophagogastric Junction Adenocarcinoma
NCT01924819 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2/PHASE3
-
Surgery With or Without Combination Chemotherapy in Treating Patients With Stomach Cancer
NCT00002615 ·Status: COMPLETED ·Phase: PHASE3
-
Compare S-1 for 6 Months to 1 Year as Adjuvant Chemotherapy After D2 Resection in Patients With Gastric Cancer Staged II , IIIA or IIIB.
NCT02736552 ·Status: WITHDRAWN ·Phase: PHASE3
-
Postoperative Sequence Chemoradiotherapy Compared With Chemotherapy Alone for Advanced Gastric Cancer
NCT01197118 ·Status: UNKNOWN ·Phase: PHASE2
-
Randomized Phase II Trial Evaluating DFS in The Absence of an Adjuvant Component of Perioperative Chemotherapy in Patients With Gastric Cancer
NCT06942663 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Duration of Adjuvant Chemotherapy for Gastric Cancer Patients at Pathological N3 Stage
NCT06194981 ·Status: RECRUITING
-
Trial of Adjuvant Chemotherapy for Gastric Cancer
NCT00296322 ·Status: COMPLETED ·Phase: PHASE3
-
A Randomized Phase III Study of Adjuvant Chemotherapy With or Without Chemo-radiotherapy in Patients With Local Advanced Gastric Cancer After D2 Resection.
NCT02648841 ·Status: UNKNOWN ·Phase: PHASE3
-
Preoperative Stomach Cancer Induction Chemotherapy and Radiation Therapy
NCT03223740 ·Status: UNKNOWN ·Phase: PHASE3
-
Postoperative Chemoradiation or Chemotherapy After Preoperative Chemotherapy for Gastric Cancers
NCT03515941 ·Status: TERMINATED ·Phase: EARLY_PHASE1
-
Study of Adjuvant Chemotherapy With or Without PD-1 Inhibitors and Chemoradiotherapy in Resected pN3 Gastric (G) or GEJ Adenocarcinoma
NCT04997837 ·Status: RECRUITING ·Phase: PHASE3
-
Combination Chemotherapy Before and After Surgery in Treating Patients With Stomach Cancer
NCT00002783 ·Status: COMPLETED ·Phase: PHASE2
-
High-Dose Chemotherapy in Treating Patients With Advanced Stomach Cancer
NCT00002722 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy Followed by Surgery and Intraperitoneal Chemotherapy in Treating Patients With Locally Advanced Stomach Cancer
NCT00006038 ·Status: COMPLETED ·Phase: PHASE2
-
Surgery With or Without Combination Chemotherapy in Treating Patients With Stomach Cancer
NCT00004099 ·Status: TERMINATED ·Phase: PHASE3
-
Adjuvant Chemoradiation Therapy for Gastric or Gastroesophageal Junction Adenocarcinoma
NCT00215514 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Effect of Adjuvant Chemotherapy Cycles on Patients With Node-negative Gastric Cancer Following Neoadjuvant Chemotherapy
NCT06277453 ·Status: ACTIVE_NOT_RECRUITING