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Characterization of New Human Models of Non-histaminergic Itch

NCT04515056 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2021-07-09

No results posted yet for this study

Summary

In this experiment the investigators would like to test a new new human itch model based on papain, and to characterize the sensory quality and temporary aspects of papain skin prick test (SPT) in comparison to the inactivated-cowhage delivery system.

Conditions

  • Papain
  • Itch
  • Skin Prick Test (SPT)

Interventions

DRUG

Papain 10 µg

The area will be exposed to 10 µg of papain.

DRUG

Papain 50 µg

The area will be exposed to 50 µg of papain.

DRUG

Papain 100 µg

The area will be exposed to 100 µg of papain.

OTHER

Vehicle

The area will be exposed to vehicle

DRUG

Papain 1 SPT

Papain will be applied by 1 SPT prick thought the skin

DRUG

Papain 5 SPT

Papain will be applied by 5 SPT pricks thought the skin

DRUG

Papain 25 SPT

Papain will be applied by 25 SPT pricks thought the skin

OTHER

Cowhage

The last area will be exposed to cowage spicules (made chemically inert by autoclaving) soaked in 5 mg/ml papain solution.

Sponsors & Collaborators

  • Aalborg University

    lead OTHER

Principal Investigators

  • Silvia Lo Vecchio · Aallborg University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-09-01
Primary Completion
2021-06-01
Completion
2021-06-01

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04515056 on ClinicalTrials.gov