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The Study of Pharmacokinetics of Levetiracetam in Patients Undergoing Intermittent Hemodialysis

NCT04511676 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 12

Last updated 2020-08-13

No results posted yet for this study

Summary

Levetiracetam (LEV) is one of second-generation antiepileptic drugs that has been used to treat partial and generalized epilepsy. LEV is eliminated from the systemic circulation by renal excretion. Therefore, patients with renal impairment may experience a reduced drug excretion and increased adverse drug reactions. Moreover, patients with end-stage renal disease who need dialysis may experience low serum LEV concentration because of drug loss via dialysis. LEV loss via dialysis can cause low serum level of LEV that insufficient for seizure control. The present study was aimed to evaluate pharmacokinetics of LEV in patients undergoing 4 hour-intermittent hemodialysis (IHD). The results of the study may benefit to determine the appropriate LEV initial dose and supplemental dose for patients undergoing IHD.

Conditions

Sponsors & Collaborators

  • Silpakorn University

    collaborator OTHER

  • Phramongkutklao College of Medicine and Hospital

    lead OTHER

Principal Investigators

  • Pasiri Sithinamsuwan, MD · Pharmongkutklao Hospital and College of Medicine

  • Daraporn Rungprai, BCP · Faculty of Pharmacy, Silpakorn University

  • Juthathip Suphanklang, BCP · Faculty of Pharmacy, Silpakorn University

  • Wongsakorn Promken, B Pharm · The College of Pharmacotherapy of Thailand

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-11-01
Primary Completion
2019-10-10
Completion
2019-10-10

Countries

  • Thailand

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04511676 on ClinicalTrials.gov