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Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients

NCT04508933 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2021-10-26

No results posted yet for this study

Summary

Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.

Conditions

  • Respiratory Distress Syndrome, Adult
  • Ventilation Perfusion Mismatch
  • Pulmonary Edema
  • Covid19

Interventions

DEVICE

Extravascular Lung Water Index

Measurement of the EVLWI

DEVICE

Pulmonary Vascular Permeability Index

Measurement of the PVPI

Sponsors & Collaborators

  • Istanbul University - Cerrahpasa

    lead OTHER

Principal Investigators

  • Yalım Dikmen, Prof · Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-01
Primary Completion
2020-09-30
Completion
2020-12-31
FDA Device
Yes

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04508933 on ClinicalTrials.gov