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A Study of MIcrocirculatory Perfusion Alterations in Severe Burn Injury

NCT04500197 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 21

Last updated 2020-10-14

No results posted yet for this study

Summary

The main objective of our study is to focus on the efficiency of standard fluid resuscitation in promoting tissue perfusion in severe burns patients (\>15% TBSA). The incidence of microcirculatory perfusion alterations, according to a predefined arbitrary cut off value, in patients with severe burns injury (\>15%TBSA) will be assessed during standard resuscitation in the first 24 hours.

Secondary objectives are to assess differences in microcirculatory perfusion alterations between early (\<12 hours post burn injury) and late standard resuscitation (\>12 hours post burn injury) with addition of albumin to the regime.

And to measure several biomarkers of glycocalyx shedding, oxidative stress and inflammation.

Conditions

  • Microcirculation
  • Burns
  • Resuscitation

Sponsors & Collaborators

  • Maasstad Hospital

    lead OTHER

Principal Investigators

  • Can Ince, Prof · Erasmus Medical Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-11-12
Primary Completion
2020-09-15
Completion
2020-09-15

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04500197 on ClinicalTrials.gov