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Vitamin D and Methotrexate Adverse Effects

NCT04488237 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2020-07-27

No results posted yet for this study

Summary

Since methotrexate toxicity represents a major problem in patients treating with cancer and there are few studies about the role of vitamin D in the pathogenesis of this toxicity, so the aim of the present study is investigation of the effect of vitamin D administration on methotrexate toxicity such as oral ulcerations, bone marrow toxicity as well as renal and hepatic toxicity also the role of inflammatory mediators and oxidative stress markers in methotrexate toxicity will be evaluated, taking in consideration the dose of leucovorin rescue.

Conditions

Interventions

DRUG

Vitamin D

oral administration of Vitamin D in patients with acute leukemia treated with methotrexate

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Principal Investigators

  • Mahmoud Hamdy Abdel-Raheem, Phd · Assiut University

  • Mohammed Mostafa Elbadr, Phd · Assiut University

  • Nivin Abdel-Azim Abdel-Rehim, Phd · Assiut University

Eligibility

Min Age
1 Year
Max Age
12 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-09-30
Primary Completion
2021-09-30
Completion
2021-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04488237 on ClinicalTrials.gov